Jie Li Shu
Jie Li Shu Uses, Dosage, Side Effects, Food Interaction and all others data.
Jie Li Shu increases cerebral metabolism; it increases glucose and O2 consumption; improves cerebral hypoxia tolerance; shifts glucose metabolism to the energetically more favourable aerobic pathway, but it increases the anaerobic pathway as well; it elevates the ATP concentration and the ATP/AMP ratio in the brain, and elevates the cerebral norepinephrine, dopamine and serotonin levels.
Jie Li Shu considerably improves cerebral microcirculation by inhibiting platelet aggregation, reducing the pathologically increased blood viscosity, and increases erythrocyte deformability. It also promotes O2 transport into the tissues by reducing the O2 affinity of erythrocytes.
It selectively and intensely increases cerebral blood flow and the share of the brain in cardiac output, it reduces cerebral vascular resistance without affecting systemic circulation (blood pressure, heart rate, cardiac output, total peripheral resistance). It does not elicit steal phenomenon; on the contrary, it primarily improves the blood supply of the injured and ischaemic area while it remains unchanged in the intact areas (inverse steal effect). It further increases blood flow which is already increased as a result of hypoxia.
| Trade Name | Jie Li Shu |
| Generic | Vinpocetine |
| Vinpocetine Other Names | CERACTIN, ETHYL APOVINCAMIN-22-OATE, Vinpocetina, Vinpocetine |
| Type | |
| Formula | C22H26N2O2 |
| Weight | Average: 350.462 Monoisotopic: 350.199428085 |
| Groups | Investigational |
| Therapeutic Class | Cerebral vasodilator & Neurosensory oxygenator drugs |
| Manufacturer | |
| Available Country | China |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
All forms of acute and chronic cerebral circulatory insufficiency: TIA (Transient Ischaemic Attack), reversible ischaemic neurological deficiency, progressive stroke, completed stroke, post-apoplectic conditions, multiinfarct dementia, cerebral arteriosclerosis, post-traumatic, hypertensive encephalopathy etc.
For the reduction of psychic or neurological symptoms of cerebral insufficiency (e.g., memory disturbances, dizziness, headache, aphasia, apraxia, locomotor disorders etc.).
Ophthalmology: It can be used for the treatment of vascular disorders of the choroid and retina due to arteriosclerosis, vasospasm, macular degeneration, arterial or venous thrombosis or embolism, and glaucoma secondary to the above mentioned disorders.
Otology: For the treatment of impaired hearing of vascular or toxic (iatrogenic) origin, presbyacusis, Meniere’s disease, cochleovestibular neuritis, tinnitus and dizziness of labyrinth origin.
For the treatment of vasovegetative symptoms of climacteric syndrome.For the treatment of vasovegetative symptoms of climacteric syndrome.
Jie Li Shu is also used to associated treatment for these conditions: Cerebrovascular stenosis, Neurological Disorders
Dosage
Jie Li Shu dosage
Jie Li Shu is taken 15-30 mg daily in 3 divided doseswith meals. The maintenance dose is 15 mg three times daily over long periods.
Side Effects
Jie Li Shu is well tolerated. In some cases transient fall of blood pressure and tachycardia may occur.
Precaution
Because Jie Li Shu can reduce the ability of blood to clot, those individuals with a tendency to bleed should avoid Jie Li Shu.
Interaction
Slight changes in prothrombin time have been noted in those adding Jie Li Shu to Warfarin dosing. The changes appear minimal. There are no other interactions reported so far. Therefore, it can be applied in combinations.
Pregnancy & Breastfeeding use
Pregnancy category- Not classified
Contraindication
Jie Li Shu is contraindicated in pregnancy and lactation. Hypersensitivity to its components is also contraindicated.
Storage Condition
Store in a cool and dry place, protected from light and moisture
Innovators Monograph
You find simplified version here Jie Li Shu
FAQ
What is Jie Li Shu good for?
Jie Li Shu is used to enhance memory and increase brain metabolism. It has also been used for ischemia and reperfusion injury, and is considered a neuroprotective agent.
Is Jie Li Shu good for memory?
It can potentially improve memory and increase brain blood flow and metabolism.
How long can I take Jie Li Shu?
You cvan take5-10 mg of Jie Li Shu three times daily for up to 4 months.
What are the common side effects of Jie Li Shu?
Jie Li Shu can cause some side effects including stomach pain, nausea, sleep disturbances, headache, dizziness, nervousness, and flushing of the face.
Can Jie Li Shu raise blood pressure?
Jie Li Shu suppressed blood pressure elevation, which is in line with the vasodilatory effect that Jie Li Shu has.
What does Jie Li Shu do for the brain?
Jie Li Shu is used to enhance memory and increase brain metabolism. It has also been used for ischemia and reperfusion injury, and is considered a neuroprotective agent.
Is Jie Li Shu safe during pregnancy?
Jie Li Shu is possibly unsafe when used in pregnant women or those who may become pregnant. Jie Li Shu might increase the risk of miscarriage and might cause harm to the fetus.
is Jie Li Shu safe during breastfeeding?
Jie Li Shu might increase the risk of miscarriage and might cause harm to the fetus. Avoid using Jie Li Shu during Breast-feeding time.
How long can I take Jie Li Shu?
Jie Li Shu may use 5-10 mg three times daily for up to 4 months.
How much Jie Li Shu can I take?
Most clinical studies have used between 5 and 30 mg Jie Li Shu given up to 3 times daily due to a short half-life (2 to 4 hours).
Is Jie Li Shu good for my brain?
Jie Li Shu was shown to increase blood flow to the brain and has been studied as a treatment for Alzheimer's disease and for disorders of the nervous and circulatory systems.
Can Jie Li Shu cause insomnia?
Jie Li Shu may causes many symtom like as indigestion, nausea, dizziness, anxiety, facial flushing. may insomnia is one of them.
How does Jie Li Shu work?
It is not known exactly how Jie Li Shu works, but it might increase blood flow to the brain and offer some protection for brain cells (neurons) against injury.
How long does Jie Li Shu stay in my system?
Most clinical studies have used between 5 and 30 mg Jie Li Shu given up to 3 times daily due to a short half-life (2 to 4 hours)
Can I drink alcohol with Jie Li Shu?
Jie Li Shu should not be used in patients with low blood pressure . As alcohol causes hypotension, it is recommended to avoid it.
Can I drive after taking Jie Li Shu?
Jie Li Shu is not known to affect your ability to drive. But caution is advised in the presence of symptoms like drowsiness, headache, anxiety or sleeplessness.
Can I take overdose of Jie Li Shu?
Jie Li Shu is a safe drug, and accidental overdose may not be harmful. But it is advised not to take high doses of this medicine (more than 20 mg a day) for long periods as it may result in unwanted effects.
What happens if I miss the dose Jie Li Shu?
Take the missed dose as early as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a higher or a double dose to compensate for the missed dose.
