Kelfizina
Kelfizina Uses, Dosage, Side Effects, Food Interaction and all others data.
Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.
Kelfizina is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
| Trade Name | Kelfizina |
| Generic | Sulfametopyrazine |
| Sulfametopyrazine Other Names | Solfametopirazina, Sulfalene, Sulfaleno, Sulfalenum, Sulfamethopyrazine |
| Type | |
| Formula | C11H12N4O3S |
| Weight | Average: 280.303 Monoisotopic: 280.06301096 |
| Groups | Approved, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Kelfizina is an antibiotic used in the treatment or prevention of bacterial infections and malaria.
For the treatment of urinary tract infection and chronic bronchitis.
Kelfizina is also used to associated treatment for these conditions: Plasmodium Infections
How Kelfizina works
Kelfizina is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. Para-aminobenzoic acid (PABA), a substrate of the enzyme is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Innovators Monograph
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