Kemodryl
Kemodryl Uses, Dosage, Side Effects, Food Interaction and all others data.
Kemodryl is an inorganic compound with the formula NH4Cl. It is highly soluble in water producing mildly acidic solutions.
Systemic acidifier. In liver ammonium chloride is converted into urea with the liberation of hydrogen ions ( which lowers the pH) and chloride.
Trade Name | Kemodryl |
Generic | Ammonium chloride |
Ammonium chloride Other Names | Ammonium chloride, Ammoniumchlorid, Chlorammonic, Chlorid ammonia |
Weight | 100mg/5ml |
Type | Syrup |
Formula | ClH4N |
Weight | Average: 53.491 Monoisotopic: 53.00322684 |
Protein binding | Data not found. |
Groups | Approved, Investigational, Vet approved |
Therapeutic Class | |
Manufacturer | Alkemy Pharmaceutical Laboratories (private) Ltd, |
Available Country | Pakistan |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
- Expectorant in cough syrups.
- The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium (Na+) to combine with fixed anions in maintaining acid-base balance, especially as a homeostatic compensatory mechanism in metabolic acidosis. The therapeutic effects of Ammonium Chloride depend upon the ability of the kidney to utilize ammonia in the excretion of an excess of fixed anions and the conversion of ammonia to urea by the liver, thereby liberating hydrogen (H+) and chloride (Cl–) ions into the extracellular fluid. Ammonium Chloride Injection, USP, after dilution in isotonic sodium chloride injection, may be indicated in the treatment of patients with: (1) hypochloremic states and (2) metabolic alkalosis.
Kemodryl is also used to associated treatment for these conditions: Allergic Reaction, Allergic cough, Common Cold, Cough, Cough caused by Common Cold, Diabetes, High Blood Pressure (Hypertension), Metabolic Alkalosis, Nasal Congestion, Nasal Congestion Due to Allergic Rhinitis, Productive cough, Rhinorrhoea, Sneezing, Bronchial congestion, Dry cough, Excess mucus or phlegm, Hypochloremic state, Airway secretion clearance therapy, Bronchodilation, Parenteral rehydration therapy, Weight Loss, Potassium
How Kemodryl works
Kemodryl increases acidity by increasing the amount of hydrogen ion concentrations.
Kemodryl can be used as an expectorant due to its irritative action on the bronchial mucosa. This effect causes the production of respiratory tract fluid which in order facilitates the effective cough.
Toxicity
LD50 "Rat" after oral administration is: 1650 mg/kg. Overdosage of Ammonium Chloride has resulted in a serious degree of metabolic acidosis, disorientation, confusion and coma. If metabolic acidosis occur following overdosage, the administration of an alkalinizing solution such as sodium bicarbonate or sodium lactate will serve to correct the acidosis.
Patients administering Kemodryl should be watched to the signs of ammonia toxicity including (pallor, sweating, irregular breathing, bradycardia, cardiac arrhythmias, local and general twitching, tonic convulsions and coma). It should be used with caution in patients with high total CO2 and buffer base secondary to primary respiratory acidosis. Intravenous administration should be slow to avoid local irritation and toxic effects.
Food Interaction
No interactions found.Volume of Distribution
Data not found.
Elimination Route
Completely absorbed within 3–6 h. In healthy persons, absorption of ammonium chloride given by mouth was practically complete. Only 1 to 3% of the dose was recovered in the feces.
Half Life
Unknown
Clearance
Data not found.
Elimination Route
Excretion: Urine
Innovators Monograph
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