Keratol 45
Keratol 45 Uses, Dosage, Side Effects, Food Interaction and all others data.
Keratol 45 is an osmotic diuretic similar to mannitol but more irritant. It induces diuresis by increasing osmotic pressure of the glomerular filtrate and increasing excretion of sodium, potassium and chloride ions. Its osmotic effect also draws water from cells e.g. brain, CSF and anterior chamber of the eye, thereby decreasing intracranial or intraocular pressure. Unlike mannitol, urea penetrates the eye and causes a rebound increase in intraocular pressure if the plasma concentration of the drug is less than that in the vitreous humour. Applied topically, urea promotes hydration of keratin and mild keratolysis in dry skin. It increases water uptake by the stratum corneum and has an antipruritic effect.
As a humectant, urea draws water into the striatum corneum.
| Trade Name | Keratol 45 |
| Availability | Rx and/or OTC |
| Generic | Urea |
| Urea Other Names | Carbamide, Carbonyldiamide, Harnstoff, Karbamid, Urea, Urée |
| Related Drugs | tolvaptan, Samsca, sodium acetate, ure-Na |
| Type | Cream |
| Formula | CH4N2O |
| Weight | Average: 60.0553 Monoisotopic: 60.03236276 |
| Groups | Approved, Investigational |
| Therapeutic Class | Topical urea preparations |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Keratol 45 25% cream is used for the treatment of dry, cracked skin and hyperkeratosis on the soles of the feet including the heels. Suitable for general and diabetic foot care.
Keratol 45 is also used to associated treatment for these conditions: Dermatitis, Dermatitis, Contact, Dermatitis, Eczematous, Dry Eyes, Dry Skin, Dry Skin; Eczema, Eczema, Dyshidrotic, Eye pruritus, Helicobacter Pylori Infection, Insect Bites, Lichen Planus (LP), Neurodermatitis, Nummular Dermatitis, Psoriasis, Seborrheic Dermatitis, Sunburn, Allergic skin manifestations, Anal eczema, Calluses, Moisturizing
Dosage
Keratol 45 dosage
Apply a small amount twice daily to the skin after washing or bathing.
In extreme cases, before bed you may choose to cover the feet with plastic wrap and then put socks over the plastic wrap to increase the hydration rate.
Recommended for use on adults and children over 12 years.
After use, wear sandals or slippers to avoid staining carpets.
Side Effects
May irritate inflamed skin or exudative lesions. Transient stinging may occur in deep cracks. Discontinue use if local irritation or rash occurs during use.
Food Interaction
No interactions found.Keratol 45 Drug Interaction
Moderate: glycerin, escitalopramUnknown: aspirin, aspirin, sulfamethoxazole / trimethoprim, ubiquinone, copper gluconate, meperidine, omega-3 polyunsaturated fatty acids, pregabalin, metoprolol, acetaminophen / hydrocodone, bioflavonoids, montelukast, levothyroxine, cyanocobalamin, ascorbic acid, ergocalciferol, cholecalciferol, cetirizine
Keratol 45 Disease Interaction
Pregnancy & Breastfeeding use
Keratol 45 cream can be used during pregnancy and lactation.
Contraindication
For use only on the soles of the feet and heels unless otherwise directed by the prescriber. Pregnant women should consult their Healthcare Professional before use. For External Use Only. Avoid contact with eyes. Keep out of reach of children. Always replace cap after use. Do not use if tube seal is broken or appears tampered with.
Storage Condition
Store between 10° – 30° C in a dry place. Keep lid tightly closed.
Innovators Monograph
You find simplified version here Keratol 45
FAQ
What is Keratol 45 used for?
Keratol 45 is used to treat dry skin conditions (e.g., eczema, psoriasis, corns, callus) and some nail problems (e.g., ingrown nails). It may also be used to help remove dead tissue in some wounds to help wound healing.
How safe urea is?
Keratol 45 can be toxic if fed at too high a level so it's important not to overfeed and mixing thoroughly is vital. The level of Keratol 45 required is low, a maximum level of 0.7% of the overall feed dry matter is advised.
What are the common side effect of Keratol 45?
Common side effects of Keratol 45 include:
- Local irritation (burning, itching, redness)
- Temporary stinging.
- Rash.
What does Keratol 45 do to the body?
Keratol 45 is known as a keratolytic agent. This means it breaks down the protein keratin in the outer layer of your skin. Keratol 45 can help reduce dead skin buildup and get rid of flaking or scaling skin.
Is Keratol 45 safe during pregnancy?
It is not known whether urea topical will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.
Is Keratol 45 safe during breastfeeding?
It is not known whether urea topical passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.
Can I drink alcohol with Keratol 45?
The presence of Keratol 45 decreases the hydrophobic effect of a monovalent alcohol, strongly at low temperatures, to a lesser degree at high temperatures . Consequently, urea hinders the interhydrophobic interactions by affecting the water molecules.
What does Keratol 45 do in the kidney?
The urea travels from your liver to your kidneys through your bloodstream.Healthy kidneys filter Keratol 45 and remove other waste products from your blood.
How does Keratol 45 help skin?
Keratol 45 providing hydration to smooth your skin's texture, and by helping to reduce the buildup of dead skin cells.
Can I use Keratol 45 on hands?
Wash your hands before and after use.Do not take Keratol 45 cream and ointment by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
Is Keratol 45 in skincare urine?
The Keratol 45 used in skin care products is made synthetically in a lab, but Keratol 45 is also naturally found on your skin and is excreted in urine.
Is Keratol 45 cream made from urine?
The Keratol 45 used in skin care products is made synthetically in a lab, but Keratol 45 is also naturally found on your skin and is excreted in urine.
How often should I use Keratol 45?
Keratol 45 usually taken 1 to 3 times a day or as directed by your doctor. Rub in well until absorbed.
What are the advantages of Keratol 45 fertilizer?
Keratol 45 has several advantages, including cost per pound of nitrogen, higher nutrient density and good handling and storage properties.
How does Keratol 45 cream work?
Keratol 45 can breaks down the protein keratin in the outer layer of your skin. This action can help reduce dead skin buildup and get rid of flaking or scaling skin.
How long does Keratol 45 fertilizer take to work?
This can occur in two to four days and happens more quickly on high pH soils.
Is Keratol 45 a toxin?
Keratol 45 exerts both direct and indirect toxic effects on several organs in the body.
What role Keratol 45 plays in liver?
Two of these are the control of amino acid concentration and detoxification.Keratol 45 is produced in the liver and is a metabolite of amino acids. Ammonium ions are formed in the breakdown of amino acids.
