Kerydin
Kerydin Uses, Dosage, Side Effects, Food Interaction and all others data.
Tavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed due to Trichophyton rubrum or Trichophyton mentagrophytes infection. Kerydin functions by inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and for the catalysis of ATP-dependent ligation of L-leucine to tRNA(Leu).
After a single dose, the mean (± standard deviation) peak concentration (Cmax) of tavaborole was 3.54 ± 2.26 ng/mL (n=21 with measurable concentrations, range 0.618-10.2 ng/mL, LLOQ=0.5 ng/mL), and the mean AUClast was 44.4 ± 25.5 nghr/mL (n=21). After 2 weeks of daily dosing, the mean Cmax was 5.17 ± 3.47 ng/mL (n=24, range 1.51-12.8 ng/mL), and the mean AUCτ was 75.8 ± 44.5 nghr/mL.
| Trade Name | Kerydin |
| Availability | Prescription only |
| Generic | Tavaborole |
| Tavaborole Other Names | Tavaborole |
| Related Drugs | terbinafine, itraconazole, Lamisil, ciclopirox topical, griseofulvin, Jublia |
| Weight | 5%, |
| Type | Topical solution |
| Formula | C7H6BFO2 |
| Weight | Average: 151.93 Monoisotopic: 152.044488 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Kerydin is an antifungal agent used to treat onychomycosis, a fungal infection of the nail.
Indicated for the treatment of onychomycosis (a fungal infection) of the toenails due to Trichophyton rubrum or Trichophyton mentagrophytes.
Kerydin is also used to associated treatment for these conditions: Onychomycosis
How Kerydin works
Kerydin exerts its antifungal activity by blocking cellular protein synthesis through the formation of an adduct with cytoplasmic leucyl-aminoacyl transfer RNA (tRNA) synthetase.
Toxicity
Kerydin is generally well tolerated with most adverse events reported as mild and not related to treatment. Treatment related adverse events that occurred in >1 % of participants include application site exfoliation, application site erythema, and application site dermatitis, and ingrown toenail.
Food Interaction
No interactions found.Elimination Route
7.5%. Subungual onychomycosis is difficult to treat due to the poorly perfused location of the infection in the nailbed. To be effective, a topical treatment must penetrate the nail plate and reach the site of infection at a concentration sufficient to exert anti-fungal activity. Kerydin was shown to produce anti-fungal effects after 5 days of topical administration.
Half Life
28.5 hr
Elimination Route
Primarily renal.
Innovators Monograph
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