Ketosteril

Ketosteril Uses, Dosage, Side Effects, Food Interaction and all others data.

Ketosteril allows the intake of essential amino acids while minimising the amino-nitrogen intake. Following absorption, the keto- and hydroxy-analogues are transaminated to the corresponding essential amino acids by taking nitrogen from non-essential amino acids, therby decreasing the formation of urea by re-using the amino group. Hence, the accumulation of uraemic toxins is reduced. Keto and hydroxy acids do not induce hyperfiltration of the residual nephrons. Ketoacid containing supplements exert positive effect on renal hyper phosphataemia and secondary hyperparathyroidism. Moreover, renal osteodystrophy may be improved. The use of Ketosteril in combination with a very low protein diet allows to reduce nitrogen intake while preventing the deleterious consequences of inadequate dietary protein intake and malnutrition.

Ketosteril
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Ketosteril
Generic	Ketosteril
Weight	600mg, 38mg, 67mg, 101mg, 105mg, 59mg, 0, 53mg, 23mg, 30mg, 3-metil-2-oxovalerat67mg, 4-metil-2-oksovalerat101mg, 2-okso-3-fenilpropionat68mg, 3-metil-2-oksobutirat86mg, 2-hidroksi-4-metiltiobutirat59mg, 36mg, 05g.
Type	Tablet, Caplet
Therapeutic Class	Drugs used in chronic kidney dialysis
Manufacturer	Fresenius Kabi, Medipak Limited, Fresenius Kabi Indonesia
Available Country	Bangladesh, Pakistan, India, Indonesia
Last Updated:	September 19, 2023 at 7:00 am

Uses

Prevention and therapy of damages due to faulty or deficient protein metabolism in chronic renal insufficiency in connection with limited protein in food of 40 g/day (for adults) ie, generally in patients with a glomerular filtration rate (GFR) 25 mL/minutes.

Dosage

Ketosteril dosage

Adults (70 kg body weight): If not otherwise prescribed, take 4 to 8 tablets three times a day during meals. Swallow whole.

Duration of Application: Ketosteril tablets are given as long as the glomerular filtration rate (GFR) is between 5 and about 15 mL/minute. Simultaneously food should contain 40 g/day protein or less (adults).

Side Effects

Hypercalcemia may develop. In this case it is recommended to decrease Vitamin D intake. If hypercalcaemia persists, reduce the dosage of Ketosteril as well as other source of calcium. The serum calcium level should be monitored regularly. Ensure sufficient calorie intake. No experience has been gained so far with the administration in paediatric patients.

Precaution

In the presence of hereditary phenylketonuria, attention should be given to the fact that Ketosteril contains phenylalanine

Interaction

Concomitant administration of calcium-containing drugs may cause or aggravate elevated serum calcium levels. Uraemic symptoms improve under therapy with Ketosteril. Thus, in case of aluminium hydroxide administration, the dose of this drug has to be reduced if necessary. Serum phosphate levels should be monitored for a decrease. Drugs that form sparingly soluble compounds with calcium (e.g. tetracyclines, quinolones such as ciprofloxacin and norfloxacin as well as drugs containing iron, fluoride or estramustine) should not be taken at the same time with Ketosteril to avoid disturbed absorption of the active substance. An interval of at least two hours should elapse between the ingestion of Ketosteril and these drugs. The susceptibility to cardioactive glycosides, and hence the risk for arrhythmia will increase in Ketosteril produces elevated serum calcium levels). Monitoring of the serum phosphate levels is needed in case of concomitant administration of aluminium hydroxide.

Pregnancy & Breastfeeding use

There are no adequate data from the use of Ketosteril in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development. Caution should be exercised when prescribing to pregnant women. No experience has been made so far with the use during lactation. No case of overdose has been reported.