Kinin Dak

Kinin Dak Uses, Dosage, Side Effects, Food Interaction and all others data.

Kinin Dak is a cinchona alkaloid and a 4-methanolquinoline. It rapidly acts on blood schizontocide by interfering with lysosomal function or nucleic acid synthesis in the Plasmodia spp. It has no activity against exoerythrocytic forms.

Kinin Dak is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Kinin Dak acts as a blood schizonticide although it also has gametocytocidal activity against P. vivax and P. malariae. Because it is a weak base, it is concentrated in the food vacuoles of P. falciparum. It is thought to act by inhibiting heme polymerase, thereby allowing accumulation of its cytotoxic substrate, heme. As a schizonticidal drug, it is less effective and more toxic than chloroquine. However, it has a special place in the management of severe falciparum malaria in areas with known resistance to chloroquine.

Trade Name Kinin Dak
Availability Prescription only
Generic Quinine
Quinine Other Names (8S,9R)-quinine, 6'-Methoxycinchonidine, Chinin, Chinine, Chininum, Quinina, Quinine
Related Drugs doxycycline, clindamycin, hydroxychloroquine, Plaquenil, Cleocin
Type
Formula C20H24N2O2
Weight Average: 324.4168
Monoisotopic: 324.183778022
Protein binding

Approximately 70%

Groups Approved
Therapeutic Class Anti-malarial drugs
Manufacturer
Available Country Denmark
Last Updated: September 19, 2023 at 7:00 am
Kinin Dak
Kinin Dak

Uses

Kinin Dak Sulfate, is an antimalarial drug used only for treatment of uncomplicated Plasmodium falciparum malaria. Kinin Dak sulfate has been shown to be effective in geographical regions where resistance to chloroquine has been documented

Kinin Dak Sulfate oral capsules are not approved for:

  • Treatment of severe or complicated P. falciparum malaria.
  • Prevention of malaria.
  • Treatment or prevention of nocturnal leg cramps

Kinin Dak Dihydrochloride is used for the acute treatment of malaria. It may also be used in the treatment of Babesiosis in conjunction with clindamycin.

Kinin Dak is also used to associated treatment for these conditions: Malaria caused by Plasmodium falciparum

How Kinin Dak works

The theorized mechanism of action for quinine and related anti-malarial drugs is that these drugs are toxic to the malaria parasite. Specifically, the drugs interfere with the parasite's ability to break down and digest hemoglobin. Consequently, the parasite starves and/or builds up toxic levels of partially degraded hemoglobin in itself.

Dosage

Kinin Dak dosage

Intravenous:

  • Adult: Initially, 20 mg/kg to max 1.4 g over 4 hr with maintenance infusion started after 8 hr. Maintenance infusions: 10 mg/kg to max 700 mg over 4 hr 8 hrly. Loading dose should not be given if patient has received quinine, quinidine, halofantrine or mefloquine during the previous 24 hr.
  • Child:≤5 mg/kg/hr by slow IV infusion.

Oral:

  • Adult: 648 mg given every 8 hr for 7 days.
  • Child: ≥8 yr10 mg/kg 8 hrly for 7 days.

Should be taken with food. Take with food to minimise GI discomfort.

Reconstitutions

Dilute in NaCl 0.9% to a concentration of diHCl 60-100 mg/mL.

Side Effects

Headache, nausea, disturbed vision, impaired hearing, tinnitus, abdominal pain, vomiting, diarrhoea, vertigo; flushing skin with intense pruritus, urticaria; fever, dyspnoea, agranulocytosis, palpitations, rashes; myalgia, muscle weakness, asthma, asthenia, disorientation, angioedema; haemoglobinuria; hypoprothrombinaemia, hypoglycaemia, hypotension, renal failure.

Toxicity

Kinin Dak is a documented causative agent of drug induced thrombocytopenia (DIT). Thrombocytopenia is a low amount of platelets in the blood. Kinin Dak induces production of antibodies against glycoprotein (GP) Ib-IX complex in the majority of cases of DIT, or more rarely, the platelet-glycoprotein complex GPIIb-IIIa. Increased antibodies against these complexes increases platelet clearance, leading to the observed thrombocytopenia.

Precaution

Patients with cardiac conduction defects, heart block or AF. Pregnancy and lactation.

Interaction

Reduced renal clearance of amantadine. Reduced clearance with cimetidine. Increased anticoagulant effect of warfarin and other anticoagulants. Reduced plasma levels of ciclosporin. Increased plasma levels of digoxin. Increased risk of myopathy and rhabdomyolysis with atorvastatin. May enhance hypoglycaemic effects of oral antidiabetics.

Food Interaction

  • Take with food. Food reduces irritation.

[Minor] Coadministration with grapefruit juice does not appear to affect the pharmacokinetics of quinine in a clinically relevant manner.

Although grapefruit juice is an inhibitor of CYP450 3A4 and quinine is metabolized by this pathway to its major metabolite, 3-hydroxyquinine, a study of ten healthy volunteers found no significant differences in quinine peak plasma concentration (Cmax), time to reach Cmax (Tmax), terminal elimination half-life, systemic exposure (AUC), or apparent oral clearance (Cl

Relative to the control period, the apparent renal clearance of quinine was markedly increased by 81% during treatment with half-strength grapefruit juice.

However, since renal clearance accounts for approximately 6% of the total clearance of quinine, this change would likely have minimal clinical impact.

The lack of a significant interaction is probably due to the fact that grapefruit juice primarily inhibits intestinal rather than hepatic CYP450 3A4, and quinine is not known to undergo significant presystemic metabolism as evidenced by its relatively high oral bioavailability (76% to 88%).

Nevertheless, excessive consumption of grapefruit juice and tonic water (which contains quinine) was suspected as the cause of torsade de pointes arrhythmia in a patient with a history of asymptomatic long QT syndrome.

Treatment with magnesium sulfate and metoprolol had no effect, but the arrhythmia resolved spontaneously 48 hours after discontinuation of the drinks.

Based on current data, moderate grapefruit juice consumption is probably safe for the majority of patients taking quinine.

Volume of Distribution

  • 1.43 ± 0.18 L/kg [Healthy Pediatric Controls]
  • 0.87 ± 0.12 L/kg [P. falciparum Malaria Pediatric Patients]
  • 2.5 to 7.1 L/kg [healthy subjects who received a single oral 600 mg dose]

Elimination Route

76 - 88%

Half Life

Approximately 18 hours

Clearance

  • 0.17 L/h/kg [healthy]
  • 0.09 L/h/kg [patients with uncomplicated malaria]
  • 18.4 L/h [healthy adult subjects with administration of multiple-dose activated charcoal]
  • 11.8 L/h [healthy adult subjects without administration of multiple-dose activated charcoal]
  • Oral cl=0.06 L/h/kg [elderly subjects]

Elimination Route

Kinin Dak is eliminated primarily via hepatic biotransformation. Approximately 20% of quinine is excreted unchanged in urine.

Pregnancy & Breastfeeding use

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Contraindication

Hypersensitivity to quinine, mefloquine or quinidine. Patients with nocturnal leg cramps; prolonged QT interval, tinnitus or optic neuritis, myasthenia gravis, G6PD deficiency, haemolysis and who had suffered from blackwater fever. Concomitant use with ritonavir, mefloquine, rifampicin, class IA and class III antiarrhythmic agents, neuromuscular blocking agents, other drugs known to cause QT prolongation, and Al- and/or Mg-containing antacids.

Special Warning

Renal Impairment:

  • Oral:Severe: Initially, 648 mg followed after 12 hr by maintenance doses of 324 mg 12 hrly.
  • Intravenous: Severe: Reduce maintenance dose to 5-7 mg/kg of quinine salt 8 hrly.

Hepatic Impairment:

  • Mild to moderate: No dosage adjustment needed.
  • Intravenous: Severe: Reduce maintenance dose to 5-7 mg/kg of quinine salt 8 hrly.

Acute Overdose

Symptoms: GI effects, CNS disturbances, oculotoxicity, cardiotoxicity,; tinnitus, abdominal pain, diarrhoea, vertigo, pulmonary oedema, hypotension, sweating, flushing, nausea, vomiting, headache, slightly disturbed vision, deafness, vasodilatation and adult resp distress syndrome.

Management: Administer multiple dose of activated charcoal within 1 hr or perform gastric lavage. Symptomatic (e.g. maintaining BP, respiration and renal function, treating arrhythmias) and supportive treatment.

Storage Condition

Store between 20-25° C. Protect from light.

Innovators Monograph

You find simplified version here Kinin Dak

Kinin Dak contains Quinine see full prescribing information from innovator Kinin Dak Monograph, Kinin Dak MSDS, Kinin Dak FDA label

FAQ

What is Kinin Dak used for?

Kinin Dak is used to treat malaria caused by Plasmodium falciparum. Plasmodium falciparum is a parasite that gets into the red blood cells in the body and causes malaria.

How safe is Kinin Dak?

Experts consider Kinin Dak safe to consume in small doses.The FDA also specify that manufacturers must place Kinin Dak on the label for consumers to easily see.

How does Kinin Dak work?

Kinin Dak works by killing the parasite or preventing it from growing.

What are the common side effects of Kinin Dak?

Common side effects of Kinin Dak are include:

  • nausea.
  • restlessness.
  • difficulty hearing or ringing in the ears.
  • confusion.
  • nervousness.

Is Kinin Dak safe during pregnancy?

You should not avoid taking Kinin Dak  because you are pregnant. The risk of harm to you and your baby from malaria is likely to be far greater than any possible risk from taking quinine. There is no convincing scientific evidence that Kinin Dak is harmful to an unborn baby.

Is Kinin Dak safe during breastfeeding?

Because of the low levels of Kinin Dak in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. The dosage in milk is far below those required to treat an infant for malaria.

Can I drive after taking Kinin Dak?

Kinin Dak may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Do not use to treat any condition that has not been checked by your doctor.

When should be best taken of Kinin Dak?

Kinin Dak usually is taken with food three times a day (every 8 hours) for 3 to 7 days. Take Kinin Dak at around the same times every day.

How much Kinin Dak can I take daily?

Adults and children 16 years of age and older 648 milligrams (mg) (2 capsules) every 8 hours for 7 days. Children younger than 16 years of age Use and dose must be determined by your doctor.

How long does it take for Kinin Dak tablets to work?

A reduction in frequency of leg cramps may take up to 4 weeks to become apparent. Patients should be monitored closely during the early stages of treatment for adverse effects. After an initial trial of 4 weeks, treatment should be stopped if there is no benefit.

How long until Kinin Dak is out of my system?

The limit of sensitivity for quinine in urine, utilizing TLC, is approximately 0.2mg/mL. Laboratory experience indicates that Kinin Dak may be detected as long as 4 to 5 days after intake.

Can I take Kinin Dak for a long time?

Long-term off-label use of Kinin Dak, still prescribed to individuals with muscle cramps despite Food and Drug Administration warnings of adverse events, is associated with an increased risk of death.

When should I stop taking Kinin Dak?

Stop taking Kinin Dak and call your doctor at once if you have headache with chest pain and severe dizziness, fast or pounding heartbeats, unusual bruising or bleeding, signs of infection, severe lower back pain, or blood in your urine.

Is Kinin Dak bad for liver?

The hepatotoxicity of Kinin Dak is usually mild and resolves within 1 to 4 weeks of stopping. In many instances, jaundice and liver test abnormalities may worsen for a few days after stopping Kinin Dak, but fatalities have not been reported, and recovery is usually rapid.

Can I just stop taking Kinin Dak?

After an initial trial of 4 weeks, treatment should be stopped if there is no benefit. Treatment should be interrupted approximately every 3 months to reassess the benefit. In patients taking Kinin Dak long term, a trial discontinuation may be considered.

How often can I take Kinin Dak ?

Adults and children aged 12 years and over, 600mg every eight hours for 7 days.

Does Kinin Dak raise blood pressure?

This tea has been used in folk medicine to treat a variety of problems, and scientists have confirmed that it lowers blood pressure as well as cholesterol.

How does Kinin Dak work in the body?

brank works by killing the parasite or preventing it from growing.

Is Kinin Dak bad for heart?

Kinin Dak can cause serious side effects on your heart, kidneys, or blood cells.

Does Kinin Dak make me sleepy?

Kinin Dak may cause hypoglycemia.

What happens if I miss a dose of Kinin Dak?

Take the Kinin Dak of dose as soon as you remember. If you are more than 4 hours late for your dose, skip the missed dose and take the medicine at your next scheduled dose time. Do not take extra medicine to make up the missed dose.

Who should not take Kinin Dak?

You should not take Kinin Dak if you have a heart rhythm disorder called Long QT syndrome, a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency, myasthenia gravis, optic neuritis (inflammation of the nerves in your eyes), if you have taken Kinin Dak in the past and it caused a blood cell disorder or severe bleeding.

What happen if I overdose on Kinin Dak?

Symptoms of overdose may include are sudden vision change, confusion, severe trouble hearing, fast/irregular heartbeat, fainting, slow/shallow breathing, seizures, inability to wake up (coma).

*** Taking medicines without doctor's advice can cause long-term problems.
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