Klotfree
Klotfree Uses, Dosage, Side Effects, Food Interaction and all others data.
(Klotfree) is an inhibitor of platelet aggregation. Lopirel (Klotfree) selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.
Klotfree is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. It has a long duration of action as it is taken once daily and a large therapeutic window as it is given in doses of 75-300mg daily.
| Trade Name | Klotfree |
| Availability | Prescription only |
| Generic | Clopidogrel |
| Clopidogrel Other Names | Clopidogrel, Clopidogrelum |
| Related Drugs | aspirin, lisinopril, metoprolol, propranolol, Xarelto, Plavix, Brilinta, enoxaparin, rivaroxaban, pravastatin |
| Type | Tablet |
| Formula | C16H16ClNO2S |
| Weight | Average: 321.822 Monoisotopic: 321.059027158 |
| Protein binding | Both the active and inactive metabolites of clopidogrel are 98% protein bound in plasma. Studies in cows show clopidogrel 71-85.5% bound to serum albumin. |
| Groups | Approved |
| Therapeutic Class | Anti-platelet drugs |
| Manufacturer | Zydus Cadila Healthcare Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
(Klotfree) is used for the reduction of atherosclerotic events (myocardial infarction, ischaemic stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Klotfree is also used to associated treatment for these conditions: Acute Coronary Syndrome (ACS), Acute Myocardial Infarction (AMI), Cardiovascular Events, Atherothrombotic events
How Klotfree works
Klotfree is metabolized to its active form by carboxylesterase-1. The active form is a platelet inhibitor that irreversibly binds to P2Y12 ADP receptors on platelets. This binding prevents ADP binding to P2Y12 receptors, activation of the glycoprotein GPIIb/IIIa complex, and platelet aggregation.
Dosage
Klotfree dosage
The recommended dose of Lopirel (Klotfree) is 75 mg once daily with or without food.
Side Effects
Generally Klotfree is well tolerated. However, a few common side effects i.e. Influenza-like symptoms, headache, upper respiratory tract infection, dizziness, muscle and back pain, and rash may occur.
Toxicity
A single dose of clopidogrel at 1500-2000mg/kg was lethal to mice and rats while 3000mg/kg was lethal to baboons. Symptoms of overdose include vomiting, breathing difficulty, gastrointestinal hemorrhage, and prostration. Klotfree is irreversibly bound to platelets for their lifetime, which is approximately 11 days. Overdoses of clopidogrel can be treated with platelet transfusions to restore clotting ability.
Precaution
As with other anti-platelet agents, Klotfree should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. Klotfree should be discontinued 7 days prior to surgery. Klotfree should be used with caution in hepatically impaired patients who may have bleeding diatheses.
Interaction
Concomitant use of Heparin, Warfarin and NSAIDs with Klotfree should be undertaken with caution. Klotfree potentiate the effect of Aspirin on collagen-induced platelet aggregation. The safety of chronic concomitant administration of Aspirin and Klotfree has not been established.
Food Interaction
- Take with or without food.
Klotfree Drug Interaction
Moderate: aspirin, aspirin, aspirin, aspirin, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acidsUnknown: ubiquinone, ubiquinone, rosuvastatin, rosuvastatin, metoprolol, metoprolol, metoprolol, metoprolol, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol
Klotfree Disease Interaction
Major: bleedingModerate: liver diseaseMinor: renal dysfunction
Volume of Distribution
The apparent volume of distribution of clopidogrel is 39,240±33,520L.
Elimination Route
A 75mg oral dose of clopidogrel is 50% absorbed from the intestine. Klotfree can be taken with or without food. A meal decreases the AUC of the active metabolite by 57%. The active metabolite of clopidogrel reaches a maximum concentration after 30-60 minutes. Klotfree reached a Cmax of 2.04±2.0ng/mL in 1.40±1.07h.
The AUC for a 300mg oral dose of clopidogrel was 45.1±16.2ng*h/mL for poor metabolizers, 65.6±19.1ng*h/mL for intermediate metabolizers, and 104.3±57.3ng*h/mL for extensive metabolizers. The Cmax was 31.3±13ng/mL for poor metabolizers, 43.9±14ng/mL for intermediate metabolizers, and 60.8±34.3ng/mL for extensive metabolizers.
Half Life
That half life of clopidogrel is approximately 6 hours following a 75mg oral dose while the half life of the active metabolite is approximately 30 minutes.
Clearance
The clearance of a 75mg oral dose was 18,960±15,890L/h and for a 300mg oral dose was 16,980±10,410L/h.
Elimination Route
An oral dose of radiolabelled clopidogrel is excreted 50% in the urine and 46% in the feces over 5 days. The remainder of clopidogrel is irreversibly bound to platelets for their lifetime, or approximately 8-11 days.
Pregnancy & Breastfeeding use
Pregnancy: There are no adequate and well-controlled studies of Klotfree in pregnant women. However, Klotfree should be used during pregnancy only if clearly needed.
Lactation: Klotfree is not recommended for use while breast-feeding. It is not known for sure whether Klotfree is excreted in breast milk, although it is suspected that it is.
Contraindication
Klotfree is contraindicated in patients with a hypersensitivity to the drug substance or any component of the product, and those with active pathological bleeding such as peptic ulcer or intracranial hemorrhage.
Special Warning
Use in children: Safety and effectiveness of Klotfree in pediatric population have not been established.
Acute Overdose
In the event of over dosage no adverse effects were reported and no therapy was substituted.
Symptoms: Prolonged bleeding time and subsequent bleeding complications.
Management: May restore clotting ability with platelet transfusion.
Storage Condition
Store at 25° C.
Innovators Monograph
You find simplified version here Klotfree
Klotfree contains Clopidogrel see full prescribing information from innovator Klotfree Monograph, Klotfree MSDS, Klotfree FDA label
FAQ
What is Klotfree used for?
Klotfree is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent. It prevents platelets from sticking together and forming a dangerous blood clot. Taking Klotfree helps prevent blood clots if you have an increased risk of having them.
How safe is Klotfree?
Klotfree is generally safe to take for a long time. In fact, it works best if you take it for many months or even years. If you're at risk of getting a stomach ulcer, your doctor may prescribe a medicine to help protect your stomach while you're taking Klotfree.
how does Klotfree work?
Klotfree slows the blood's clotting action by making platelets less sticky. Platelets are blood cells that stick together to block cuts and breaks in blood vessels. But if you're at risk of heart attack or stroke, platelets can stick together inside already narrowed blood vessels to form a clot.
What are the common side effects of Klotfree?
Common side effects of Klotfree are include:
- excessive tiredness.
- headache.
- dizziness.
- nausea.
- vomiting.
- stomach pain.
- diarrhea.
- nosebleed.
Is Klotfree safe during pregnancy?
Klotfree can be used throughout pregnancy. There may be another issue related to delivery, however. The patient in question is planning to have a repeat cesarean, and there is some evidence that Klotfree may cause more hemorrhagic complications of surgery.
Is Klotfree safe during breastfeeding?
The manufacturer reports that no adverse effects have been observed in breastfed infants with maternal Klotfree use during lactation in a small number of postmarketing cases.
Can I drink alcohol with Klotfree?
You can drink alcohol with Klotfree. But do not drink too much while taking this medicine.
When should be taken of Klotfree?
It is usually taken once a day with or without food. Take Klotfree at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Can I take Klotfree on an empty stomach?
You can be taken with or without food.
How long does Klotfree take to work?
Klotfree works within 2 hours of taking it.
How is Klotfree eliminated from the body?
An oral dose of radiolabelled Klotfree is excreted 50% in the urine and 46% in the feces over 5 days. The remainder of Klotfree is irreversibly bound to platelets for their lifetime, or approximately 8-11 days.
Is it safe to take Klotfree every other day?
Long term dual anti-platelet therapy with aspirin 81 mg daily and Klotfree 75 mg every other day beyond 12 months after PCI with DES may be a safe and efficacious cost-saving strategy to prevent VLST.
What is Klotfree half-life?
Oral dose of 75 mg, Klotfree has a half-life of approximately 6 hours.
Can I take Klotfree for a long time?
Klotfree oral tablet is used for long-term treatment. It comes with serious risks if you don't take it as prescribed. If you stop taking the drug or don't take it at all: You increase your risk of heart attack or stroke. These conditions can be fatal.
Who should not take Klotfree?
You should not use Klotfree if you have any active bleeding such as a stomach ulcer or bleeding in the brain.Klotfree increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop, if you have blood in your urine, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds.
What happens if I miss a dose?
Take Klotfree as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention.Overdose can cause excessive bleeding.
Can Klotfree cause heart attacks?
Klotfree may be at increased risk of serious problems like heart attacks or strokes.
Does Klotfree affect the kidneys?
In summary, among patients hospitalized with ACS and treated with Klotfree, lower levels of kidney function were associated with a greater risk of death, hospitalization for AMI, and major bleeding.
Does Klotfree affect sleep?
Klotfree are among the most prescribed drugs in cardiology and are not cited as causing insomnia or sleepiness.
Does Klotfree affect the liver?
Liver damage is a rare side effect of Klotfree.
Does Klotfree weaken immune system?
Klotfree may also cause weak immunosuppression that might contribute to risk of fatal infections.
