Kombina Forte

Kombina Forte Uses, Dosage, Side Effects, Food Interaction and all others data.

Kombina Forte, a diaminopyrimidine, is a reversible inhibitor of dihydrofolate reductase. It inhibits the conversion of bacterial dihydrofolic acid to tetrahydrofolic acid necessary for the synthesis of nucleic acids and proteins. It is either bacteriostatic or bacteriocidal, acting on the same metabolic pathway as sulfonamides.

Kombina Forte exerts its antimicrobial effects by inhibiting an essential step in the synthesis of bacterial nucleic acids and proteins. It has shown activity against several species of gram-negative bacteria, as well as coagulase-negative Staphylococcus species. Resistance to trimethoprim may arise via a variety of mechanisms, including alterations to the bacterial cell wall, overproduction of dihydrofolate reductase, or production of resistant dihydrofolate reductase. Rarely, trimethoprim can precipitate the development of blood disorders (e.g. thrombocytopenia, leukopenia, etc.) which may be preceded by symptoms such as sore throat, fever, pallor, and or purpura - patients should be monitored closely for the development of these symptoms throught the course of therapy.

As antimicrobial susceptibility patterns are geographically distinct, local antibiograms should be consulted to ensure adequate coverage of relevant pathogens prior to use.

Trade Name Kombina Forte
Availability Prescription only
Generic Trimethoprim
Trimethoprim Other Names Trimethoprim, Triméthoprime, Trimethoprimum, Trimetoprima
Related Drugs amoxicillin, doxycycline, ciprofloxacin, cephalexin, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin, amoxicillin / clavulanate
Type Tablet
Formula C14H18N4O3
Weight Average: 290.3177
Monoisotopic: 290.137890462
Protein binding

Trimethoprim is 44% bound to plasma proteins, though the specific proteins to which it binds have not been elucidated.

Groups Approved, Vet approved
Therapeutic Class Miscellaneous Antibiotics
Manufacturer Deys Medical
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Kombina Forte
Kombina Forte

Uses

For the treatment of initial episodes of uncomplicated urinary tract infections due to susceptible strains of the following organisms: Escherichiacoli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species and coagulase-negative Staphylococcus species, including S. saprophyticus.

Cultures and susceptibility tests should be performed to determine the susceptibility of the bacteria to trimethoprim. Therapy may be initiated prior to obtaining the results of these tests.

Kombina Forte is also used to associated treatment for these conditions: Acute Exacerbation of Chronic Bronchitis (AECB) caused by susceptible bacteria, Acute Otitis Media caused by susceptible bacteria, Bacterial Conjunctivitis caused by susceptible bacteria, Blepharoconjunctivitis caused by susceptible bacteria, Brucellosis, Dysentery, Bacillary, Nocardiosis, Pneumocystis Jirovecii Pneumonia, Urinary Tract Infection caused by susceptible bacteria, Bacterial blepharitis caused by susceptible bacteria, Susceptible Cholera, Susceptible Enteritis infectious caused by Shigella flexneri, Susceptible Enteritis infectious caused by Shigella sonnei, Susceptible Travelers' Diarrhea caused by Enterotoxigenic E. Coli (ETEC) Infection, Uncomplicated Urinary Tract Infection caused by susceptible bacteria

How Kombina Forte works

Kombina Forte is a reversible inhibitor of dihydrofolate reductase, one of the principal enzymes catalyzing the formation of tetrahydrofolic acid (THF) from dihydrofolic acid (DHF). Tetrahydrofolic acid is necessary for the biosynthesis of bacterial nucleic acids and proteins and ultimately for continued bacterial survival - inhibiting its synthesis, then, results in bactericidal activity. Kombina Forte binds with a much stronger affinity to bacterial dihydrofolate reductase as compared to its mammalian counterpart, allowing trimethoprim to selectively interfere with bacterial biosynthetic processes.

Kombina Forte is often given in combination with sulfamethoxazole, which inhibits the preceding step in bacterial protein synthesis - given together, sulfamethoxazole and trimethoprim inhibit two consecutive steps in the biosynthesis of bacterial nucleic acids and proteins. As a monotherapy trimethoprim is considered bacteriostatic, but in combination with sulfamethoxazole is thought to exert bactericidal activity.

Dosage

Kombina Forte dosage

The usual oral adult dosage is 100 mg of trimethoprim every 12 hours or 200 mg trimethoprim every 24 hours, each for 10 days.

The use of trimethoprim in patients with acreatinineclearance of less than 15 ml/min is not recommended.

For patients with a creatinine clearance of 15 to 30 ml/min, the dose should be 50 mg every 12 hours

Side Effects

Pruritus, rash, urticaria, mild GI disturbance (e.g. nausea, vomiting, glossitis, sore mouth); disturbance of liver enzymes, photosensitivity, angioedema, myalgia, headache; hyperkalaemia, hyponatraemia; agranulocytosis. Rarely, fever, cholestatic jaundice, exfoliative dermatitis, anaphylaxis, aseptic meningitis, megaloblastic anaemia, thrombocytopenia, leucopenia, neutropenia, methaemoglobinaemia.

Toxicity

The oral LD50 in mice and rats is 2764 mg/kg and >5300 mg/kg, respectively.

Prescribing information for trimethoprim states that signs of overdose may be evident following ingestion of doses >1 gram, and may include nausea, vomiting, dizziness, headaches, mental depression, confusion, and bone marrow depression. Treatment should consist of general supportive measures and gastric lavage, if applicable. Urinary acidification may increase renal elimination of trimethoprim. Hemodialysis is only moderately effective in eliminating trimethoprim and peritoneal dialysis is of no benefit.

Precaution

Patient with actual or potential folate deficiency (e.g. malnourished, chronic anticonvulsant therapy, elderly). Hepatic and renal impairment. Childn (esp those with fragile X chromosome associated with mental retardation). Pregnancy and lactation.

Interaction

May increase concentration of dapsone. Increased elimination and shortened elimination half-life with rifampicin. Increases concentration of phenytoin, digoxin, procainamide, rosiglitazone, repaglinide, zidovudine, zalcitabine, lamivudine. Increased risk of nephrotoxicity with ciclosporin. Potentiates anticoagulant effect of warfarin. May cause hyponatraemia with diuretics. May cause megaloblastic anaemia with other folate inhibitors (e.g. pyrimethamine, methotrexate). May increase potential for bone marrow aplasia with bone barrow depressants. Increased risk of hyperkalaemia with ACE inhibitors.

Food Interaction

No interactions found.

Volume of Distribution

Kombina Forte is extensively distributed into various tissues following oral administration. It distributes well into sputum, middle ear fluid, and bronchial secretions. Kombina Forte distributes efficiently into vaginal fluids, with observed concentrations approximately 1.6-fold higher than those seen in the serum. It may pass the placental barrier and into breast milk. Kombina Forte is also sufficiently excreted in the feces to markedly reduce and/or eliminate trimethoprim-susceptible fecal flora.

Elimination Route

Steady-state concentrations are achieved after approximately 3 days of repeat administration. Average peak serum concentrations of approximately 1 µg/mL (Cmax) are achieved within 1 to 4 hours (Tmax) following the administration of a single 100mg dose. Kombina Forte appears to follow first-order pharmacokinetics, as a single 200mg dose results in serum concentrations approximately double that of a 100mg dose. The steady-state AUC of orally administered trimethoprim is approximately 30 mg/L·h.

Half Life

Kombina Forte half-life ranges from 8-10 hours, but may be prolonged in patients with renal dysfunction.

Clearance

Following oral administration, the renal clearance of trimethoprim has been variably reported between 51.7 - 91.3 mL/min.

Elimination Route

Approximately 10-20% of an ingested trimethoprim dose is metabolized, primarily in the liver, while a large portion of the remainder is excreted unchanged in the urine. Following oral administration, 50% to 60% of trimethoprim is excreted in the urine within 24 hours, approximately 80% of which is unchanged parent drug.

Pregnancy & Breastfeeding use

Pregnancy Category C. Kombina Forte has been shown to be teratogenic in the rat when given in doses 40 times the human dose. In some rabbit studies, the overall increase in fetal loss (dead and resorbed and malformed conceptuses) was associated with doses six times the human therapeutic dose.

Nursing Mothers: Kombina Forte is excreted in human milk. Because trimethoprim may interfere with folic acid metabolism, caution should be exercised when trimethoprim is administered to a nursing woman.

Contraindication

Hypersensitivity. Blood dyscrasias (e.g. megaloblastic anaemia).

Special Warning

Pediatric Use: Safety and effectiveness in pediatric patients below the age of 2 months have not been established. The effectiveness of Kombina Forte as a single agent has not been established in pediatric patients under 12 years of age.

Geriatric Use: Clinical studies of Kombina Forte tablets did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in response between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.

Case reports of hyperkalemia in elderly patients receiving trimethoprim-sulfamethoxazole have been published. Kombina Forte is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor potassium concentrations and to monitor renal function by calculating creatinine clearance.

Acute Overdose

Symptoms: Nausea, vomiting, dizziness, headache, mental depression, confusion, bone marrow depression (e.g. thrombocytopenia, leucopenia, megaloblastic anaemia).

Management: Symptomatic and supportive treatment. May employ gastric lavage and forced diuresis. Enhance elimination through urine acidification. May administer Ca folinate (5-15 mg daily) if bone marrow depression occurs.

Storage Condition

Store between 15-25˚C. Protect from light

Innovators Monograph

You find simplified version here Kombina Forte

FAQ

What is Kombina Forte used for?

Kombina Forte used to treat and prevent urinary tract infections, such as cystitis. Occasionally, Kombina Forte is used to treat other types of infections, such as chest infections and acne.

How safe is Kombina Forte?

Kombina Forte is associated with a greater risk of acute kidney injury and hyperkalaemia compared with other antibiotics used to treat UTIs, but not a greater risk of death.

What are the common side effects of Kombina Forte?

Common side effects of Kombina Forte are include:

Diarrhea, nausea, vomiting, stomach upset, loss of appetite, changes in taste, and headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Is Kombina Forte safe during pregnancy?

Kombina Forte  isn't the safest antibiotic to take in pregnancy. Doctors generally agree you should take it only if the benefits outweigh the risks. It's been linked with a small risk of problems for the unborn baby if it's taken in early pregnancy.

Is Kombina Forte safe during breastfeeding?

If your doctor or health visitor says your baby is healthy, you can take Kombina Forte while breastfeeding.Kombina Forte passes into breast milk in small amounts and is unlikely to cause side effects in your baby.

Can Kombina Forte cause kidney problems?

Kombina Forte is associated with greater risk of acute kidney injury and among the general population aged 65 and over, and not just those treated with renin-angiotensin system blockers.

Does Kombina Forte cause anxiety?

The toxic drug levels of Kombina Forte can result in the exacerbation of depression and anxiety.

When is the best time to take Kombina Forte?

Take Kombina Forte on an empty stomach, 1 hour before or 2 hours after meals. However, if you experience nausea, you may take Kombina Forte with food. Drink at least eight glasses of liquid.

Who should not take Kombina Forte?

You should not use Kombina Forte if you are allergic to it, or if you have: anemia caused by a folate (folic acid) deficiency.

Does Kombina Forte cause renal failure?

Renal failure is not a recognised side effect of Kombina Forte, although manufacturers advise caution when treating elderly people and people with impaired renal function.

Does Kombina Forte cause anxiety?

The toxic drug levels of Kombina Forte can result in the exacerbation of depression and anxiety.

Can Kombina Forte cause insomnia?

Kombina Forte may causes insomnia with other common side effects.

Should I take Kombina Forte with food?

Kombina Forte may be taken with or without food. Follow the directions on your prescription label carefully, and ask your pharmacist or doctor to explain any part you do not understand.

Can I drink alcohol with Kombina Forte?

No, you should not drink alcohol while taking Kombina Forte else you may experience unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Drinking any amount of alcohol can result in such side effects.

How to use Kombina Forte?

Take Kombina Forte by mouth with or without food as directed by your doctor, usually once or twice daily. The dosage is based on your medical condition and response to treatment. In children, the dosage is also based on their weight.

What happens if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Can I overdose on Kombina Forte?

Overdose symptoms may include nausea, vomiting, headache, dizziness, confusion, depression, fever, chills, or flu-like symptoms. Overdose can occur slowly over a long period of time if your daily doses are too high.

Can Kombina Forte affect kidneys?

Kombina Forte is associated with a greater risk of acute kidney injury.

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*** Taking medicines without doctor's advice can cause long-term problems.
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