Korsavin
Korsavin Uses, Dosage, Side Effects, Food Interaction and all others data.
Korsavin increases cerebral metabolism; it increases glucose and O2 consumption; improves cerebral hypoxia tolerance; shifts glucose metabolism to the energetically more favourable aerobic pathway, but it increases the anaerobic pathway as well; it elevates the ATP concentration and the ATP/AMP ratio in the brain, and elevates the cerebral norepinephrine, dopamine and serotonin levels.
Korsavin considerably improves cerebral microcirculation by inhibiting platelet aggregation, reducing the pathologically increased blood viscosity, and increases erythrocyte deformability. It also promotes O2 transport into the tissues by reducing the O2 affinity of erythrocytes.
It selectively and intensely increases cerebral blood flow and the share of the brain in cardiac output, it reduces cerebral vascular resistance without affecting systemic circulation (blood pressure, heart rate, cardiac output, total peripheral resistance). It does not elicit steal phenomenon; on the contrary, it primarily improves the blood supply of the injured and ischaemic area while it remains unchanged in the intact areas (inverse steal effect). It further increases blood flow which is already increased as a result of hypoxia.
| Trade Name | Korsavin |
| Generic | Vinpocetine |
| Vinpocetine Other Names | CERACTIN, ETHYL APOVINCAMIN-22-OATE, Vinpocetina, Vinpocetine |
| Type | |
| Formula | C22H26N2O2 |
| Weight | Average: 350.462 Monoisotopic: 350.199428085 |
| Groups | Investigational |
| Therapeutic Class | Cerebral vasodilator & Neurosensory oxygenator drugs |
| Manufacturer | |
| Available Country | Russia |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
All forms of acute and chronic cerebral circulatory insufficiency: TIA (Transient Ischaemic Attack), reversible ischaemic neurological deficiency, progressive stroke, completed stroke, post-apoplectic conditions, multiinfarct dementia, cerebral arteriosclerosis, post-traumatic, hypertensive encephalopathy etc.
For the reduction of psychic or neurological symptoms of cerebral insufficiency (e.g., memory disturbances, dizziness, headache, aphasia, apraxia, locomotor disorders etc.).
Ophthalmology: It can be used for the treatment of vascular disorders of the choroid and retina due to arteriosclerosis, vasospasm, macular degeneration, arterial or venous thrombosis or embolism, and glaucoma secondary to the above mentioned disorders.
Otology: For the treatment of impaired hearing of vascular or toxic (iatrogenic) origin, presbyacusis, Meniere’s disease, cochleovestibular neuritis, tinnitus and dizziness of labyrinth origin.
For the treatment of vasovegetative symptoms of climacteric syndrome.For the treatment of vasovegetative symptoms of climacteric syndrome.
Korsavin is also used to associated treatment for these conditions: Cerebrovascular stenosis, Neurological Disorders
Dosage
Korsavin dosage
Korsavin is taken 15-30 mg daily in 3 divided doseswith meals. The maintenance dose is 15 mg three times daily over long periods.
Side Effects
Korsavin is well tolerated. In some cases transient fall of blood pressure and tachycardia may occur.
Precaution
Because Korsavin can reduce the ability of blood to clot, those individuals with a tendency to bleed should avoid Korsavin.
Interaction
Slight changes in prothrombin time have been noted in those adding Korsavin to Warfarin dosing. The changes appear minimal. There are no other interactions reported so far. Therefore, it can be applied in combinations.
Pregnancy & Breastfeeding use
Pregnancy category- Not classified
Contraindication
Korsavin is contraindicated in pregnancy and lactation. Hypersensitivity to its components is also contraindicated.
Storage Condition
Store in a cool and dry place, protected from light and moisture
Innovators Monograph
You find simplified version here Korsavin
FAQ
What is Korsavin good for?
Korsavin is used to enhance memory and increase brain metabolism. It has also been used for ischemia and reperfusion injury, and is considered a neuroprotective agent.
Is Korsavin good for memory?
It can potentially improve memory and increase brain blood flow and metabolism.
How long can I take Korsavin?
You cvan take5-10 mg of Korsavin three times daily for up to 4 months.
What are the common side effects of Korsavin?
Korsavin can cause some side effects including stomach pain, nausea, sleep disturbances, headache, dizziness, nervousness, and flushing of the face.
Can Korsavin raise blood pressure?
Korsavin suppressed blood pressure elevation, which is in line with the vasodilatory effect that Korsavin has.
What does Korsavin do for the brain?
Korsavin is used to enhance memory and increase brain metabolism. It has also been used for ischemia and reperfusion injury, and is considered a neuroprotective agent.
Is Korsavin safe during pregnancy?
Korsavin is possibly unsafe when used in pregnant women or those who may become pregnant. Korsavin might increase the risk of miscarriage and might cause harm to the fetus.
is Korsavin safe during breastfeeding?
Korsavin might increase the risk of miscarriage and might cause harm to the fetus. Avoid using Korsavin during Breast-feeding time.
How long can I take Korsavin?
Korsavin may use 5-10 mg three times daily for up to 4 months.
How much Korsavin can I take?
Most clinical studies have used between 5 and 30 mg Korsavin given up to 3 times daily due to a short half-life (2 to 4 hours).
Is Korsavin good for my brain?
Korsavin was shown to increase blood flow to the brain and has been studied as a treatment for Alzheimer's disease and for disorders of the nervous and circulatory systems.
Can Korsavin cause insomnia?
Korsavin may causes many symtom like as indigestion, nausea, dizziness, anxiety, facial flushing. may insomnia is one of them.
How does Korsavin work?
It is not known exactly how Korsavin works, but it might increase blood flow to the brain and offer some protection for brain cells (neurons) against injury.
How long does Korsavin stay in my system?
Most clinical studies have used between 5 and 30 mg Korsavin given up to 3 times daily due to a short half-life (2 to 4 hours)
Can I drink alcohol with Korsavin?
Korsavin should not be used in patients with low blood pressure . As alcohol causes hypotension, it is recommended to avoid it.
Can I drive after taking Korsavin?
Korsavin is not known to affect your ability to drive. But caution is advised in the presence of symptoms like drowsiness, headache, anxiety or sleeplessness.
Can I take overdose of Korsavin?
Korsavin is a safe drug, and accidental overdose may not be harmful. But it is advised not to take high doses of this medicine (more than 20 mg a day) for long periods as it may result in unwanted effects.
What happens if I miss the dose Korsavin?
Take the missed dose as early as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a higher or a double dose to compensate for the missed dose.
