Kwiknic Pann Flav
Kwiknic Pann Flav Uses, Dosage, Side Effects, Food Interaction and all others data.
Kwiknic Pann Flav, a pyridine alkaloid, is a stereo-selective nicotinic-cholinergic receptor agonist. Low doses cause an initial stimulation of autonomic ganglia, adrenal medulla, neuromuscular junction, and brain. High doses produce initial ganglionic stimulation followed by inhibition of neurotransmission leading to subsequent persistent depression of receptor activity.
Kwiknic Pann Flav, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Kwiknic Pann Flav exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Kwiknic Pann Flav is a highly addictive substance. Kwiknic Pann Flav also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Kwiknic Pann Flav inhalers and patches are used to treat smoking withdrawl syndrome. Kwiknic Pann Flav is classified as a stimulant of autonomic ganglia.
| Trade Name | Kwiknic Pann Flav |
| Availability | Rx and/or OTC |
| Generic | Nicotine |
| Nicotine Other Names | (S)-Nicotine, Nicotina, Nicotine, Nicotine betadex, Nicotine polacrilex, Nikotin, Nikotyna |
| Related Drugs | bupropion, Chantix, varenicline, Zyban, Nicoderm CQ, Nicorette |
| Type | Chew Gums |
| Formula | C10H14N2 |
| Weight | Average: 162.2316 Monoisotopic: 162.115698458 |
| Protein binding | Less than 5% |
| Groups | Approved |
| Therapeutic Class | Drugs used in substance dependence |
| Manufacturer | Itc Limited |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Cognitive enhancer, Smoking cessation, Smoking cessation aid
Kwiknic Pann Flav is also used to associated treatment for these conditions: Dental Cavity, Nicotine Withdrawal
How Kwiknic Pann Flav works
Kwiknic Pann Flav is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed up of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. This leads to depolarization, which activates voltage-gated calcium channels and allows more calcium to enter the axon terminal. Calcium stimulates vesicle trafficking towards the plasma membrane and the release of dopamine into the synapse. Dopamine binding to its receptors is responsible the euphoric and addictive properties of nicotine. Kwiknic Pann Flav also binds to nicotinic acetylcholine receptors on the chromaffin cells in the adrenal medulla. Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels. Calcium triggers the release of epinephrine from intracellular vesicles into the bloodstream, which causes vasoconstriction, increased blood pressure, increased heart rate, and increased blood sugar.
Dosage
Kwiknic Pann Flav dosage
Buccal:As chewing gum containing 2 mg or 4 mg nicotine polacrilex: Smokers of ≤20 cigarettes daily: Start with 2 mg chewed slowly and parked between cheek and gum over 30 min when urge to smoke occurs. Smokers of >20 cigarettes daily: Start with 4 mg. Max: 15 gums daily. As lozenge containing 1, 1.5, 2 or 4 mg nicotine polacrilex or tartrate: Initially, 1 loz 1-2 hrly allowing to slowly dissolve for 20-30 min. Usual dose: 8-12 loz daily. Max: 30 loz (1-mg strength) or 15 loz (higher strengths) daily. Continue treatment for up to 3 mth, then withdraw gradually.
Sublingual:As tab containing 2 mg nicotine β-cyclodextrin complex: 1-2 tab hrly, increased as necessary. Max: 40 tab daily. Continue treatment for up to 3 mth, then withdraw gradually.
Loz: May be taken with or without food. Suck until the taste becomes strong. Then, lodge the loz between the gum & cheek. When the taste fades, start sucking it again. Repeat until the loz completely dissolves (about 30 min). Do not swallow. Avoid coffee, acidic drinks or soft drinks for 15 min prior to sucking the loz.
Gum: May be taken with or without food. Chew gum until the taste becomes strong, then rest it between the gums & the cheek. When the taste fades, start chewing it again. Repeat the chewing routine for 30 min.
Side Effects
Nausea, vomiting, abdominal pain, diarrhoea, headache, dizziness, hiccups, flu-like symptoms, palpitations, insomnia, vivid dreams, myalgia, chest pain, anxiety, irritability, somnolence, dysmenorrhoea; mouth (e.g. aphthous ulceration) and throat irritation; nasal irritation, epistaxis, lachrymation, salivation, swelling of the tongue (gum); unpleasant taste (loz); cough, rhinitis, stomatitis, sinusitis, dry mouth (inhalator); ear sensations (nasal spray); skin reactions (patch).
Toxicity
Symptoms of overdose include nausea, abdominal pain, vomiting, diarrhea, diaphoresis, flushing, dizziness, disturbed hearing and vision, confusion, weakness, palpitations, altered respiration and hypotension. LD50= 24 mg/kg (orally in mice).
Precaution
Patient with CV disease (e.g. MI, severe arrhythmia, unstable angina pectoris, CVA, uncontrolled HTN), peripheral vascular disease, endocrine disorder (e.g. phaeochromocytoma, hyperthyroidism, DM), peptic ulcer, and skin disease (patch). Hepatic and renal impairment. Childn. Pregnancy and Lactation.
Interaction
May enhance the haemodynamic effects of adenosine. Decreased metabolism leading to increased plasma concentrations with methoxsalen.
Food Interaction
- Take separate from meals. For nicotine gum, lozenges, and oral sprays, avoid eating and drinking for 15 minutes before and during its use.
Kwiknic Pann Flav Drug Interaction
Unknown: aripiprazole, amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, contained in alcoholic beverages , diphenhydramine, duloxetine, omega-3 polyunsaturated fatty acids, clonazepam, lamotrigine, escitalopram, pregabalin, fluoxetine, quetiapine, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol, lisdexamfetamine, alprazolam, sertraline
Kwiknic Pann Flav Disease Interaction
Major: CVD/PVD, pheochromocytomaModerate: diabetes, hyperthyroidism, liver disease, PUD
Volume of Distribution
- 2 to 3 L/kg
Elimination Route
Absorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.
Half Life
Cotinine has a half life of 15-20 hours, while nicotine has a half life of 1-3 hours
Clearance
- 1.2 L/min [healthy adult smoker]
Elimination Route
About 10% of the nicotine absorbed is excreted unchanged in the urine.
Pregnancy & Breastfeeding use
Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Contraindication
Recent cerebrovascular accident. Self-medication in patients who will continue to smoke, chew tobacco, or use snuff or other nicotine-containing preparations. Non-smokers and occasional smokers.
Acute Overdose
Symptoms: Burning of the mouth and throat, nausea, vomiting, salivation, abdominal pain, diarrhoea, sweating, headache, dizziness, hearing and visual disturbances, weakness, confusion, syncope, prostration, dyspnoea, tachycardia, hypotension, rapid or weak or irregular pulse, seizure, resp failure, circulatory collapse, coma.
Management: Symptomatic and supportive treatment. Artificial respiration is instituted if necessary. Employ activated charcoal to reduce GI absorption. For TTS, the skin should be washed with water without using soap and dried.
Storage Condition
Store below 25˚ C. Protect from light and moisture.
Innovators Monograph
You find simplified version here Kwiknic Pann Flav
FAQ
What is Kwiknic Pann Flav used for?
Kwiknic Pann Flav used recreationally as a stimulant and anxiolytic. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. Kwiknic Pann Flav is used to help treat addiction to or dependence on smoking cigarettes.
How safe is Kwiknic Pann Flav?
Kwiknic Pann Flav is a dangerous and highly addictive chemical. It can cause an increase in blood pressure, heart rate, flow of blood to the heart and a narrowing of the arteries.
How does Kwiknic Pann Flav work?
Kwiknic Pann Flav works by stimulating our nervous system to release specific chemical messengers (hormones and neurotransmitters) that affect different parts of our brain and body.
What are the common side effects of Kwiknic Pann Flav?
Common side effects of Kwiknic Pann Flav are decreased appetite, heightened mood, increased heart rate and blood pressure, nausea, diarrhea, better memory, and increased alertness.
Is Kwiknic Pann Flav safe during pregnancy?
Kwiknic Pann Flav are not safe to use during pregnancy.
Is Kwiknic Pann Flav safe during breastfeeding?
Kwiknic Pann Flav can be passed from a breastfeeding mother who uses tobacco to her infant through breast milk.
Is Kwiknic Pann Flav good with alcohol?
Alcohol consumption and cigarette smoking often go hand in hand. A rodent study has found that low doses of alcohol and nicotine can have an additive effect on the release of the neurotransmitter dopamine.
Can I drive after taking Kwiknic Pann Flav ?
High levels of Kwiknic Pann Flav can also impair driving causing dizziness and light-headedness. While this may pass in a few seconds, accidents can happen in the blink of an eye. If you have to vape while driving, keep this in mind, take more shallow hits, or consider reducing your Kwiknic Pann Flav level.
When should be taken of Kwiknic Pann Flav?
It is usually taken at least 15 minutes after eating or drinking.
How often should I take Kwiknic Pann Flav ?
A schedule of 1 to 2 pieces per hour is common.
How long can I take Kwiknic Pann Flav?
Kwiknic Pann Flav gum is usually recommended for 6 to 12 weeks, with the maximum being 6 months.
How long does Kwiknic Pann Flav take to work?
Kwiknic Pann Flav acts quickly in the body. When smoked, the substance enters the bloodstream and makes it to the brain within 20 seconds.
How long does Kwiknic Pann Flav take to work?
Generally, Kwiknic Pann Flav will leaves your blood within 1 to 3 days after you stop using tobacco, and cotinine will be gone after 1 to 10 days. Neither Kwiknic Pann Flav nor cotinine will be detectable in your urine after 3 to 4 days of stopping tobacco products.
Who should not use Kwiknic Pann Flav?
Tell your doctor if you have or have ever had a heart attack, heart disease, irregular heart rate, ulcers, diabetes, or high blood pressure not controlled by medication; if you are under 18 years of age; or if you are on a sodium-restricted diet.
Is Kwiknic Pann Flav good for my brain?
Preclinical models and human studies have demonstrated that Kwiknic Pann Flav has cognitive-enhancing effects, including improvement of fine motor functions, attention, working memory, and episodic memory.
How much Kwiknic Pann Flav a day is safe?
Standard textbooks, databases, and safety sheets consistently state that the lethal dose for adults is 60 mg or less (30–60 mg), leading to safety warnings that ingestion of five cigarettes or 10 ml of a dilute Kwiknic Pann Flav-containing solution could kill an adult.
Does Kwiknic Pann Flav cause dementia?
There is strong evidence that smoking can increase your risk of dementia.
What happen If I stop taking Kwiknic Pann Flav?
Kwiknic Pann Flav withdrawal involves physical, mental, and emotional symptoms. The first week, especially days 3 through 5, is always the worst. That's when the Kwiknic Pann Flav has finally cleared out of your body and you'll start getting headaches, cravings, and insomnia. Most relapses happen within the first two weeks of quitting.
What happens if I overdose?
There are a number of symptoms you want to watch for if you are worried about a possible Kwiknic Pann Flav overdose. Within the first 15 minutes to an hour of being exposed, symptoms would create a stimulating effect such as: Nausea or vomiting. Stomachache and loss of appetite.
How long will I miss Kwiknic Pann Flav ?
Cigarette cravings typically peak in the first few days after quitting and diminish greatly over the course of the first month without smoking. 1 While you might miss smoking from time to time, once you make it past six months, the urge to smoke will be diminished or even gone.
Can Kwiknic Pann Flav affects my heart ?
Kwiknic Pann Flav can cause an increase in blood pressure, heart rate, flow of blood to the heart and a narrowing of the arteries (vessels that carry blood). Kwiknic Pann Flav may also contribute to the hardening of the arterial walls, which in turn, may lead to a heart attack.
Is Kwiknic Pann Flav hard on the kidneys?
Kwiknic Pann Flav increases the severity of renal injury in animal models including acute kidney injury, diabetes, acute nephritis and subtotal nephrectomy. The renal effects of nicotine are also linked to increased generation of reactive oxygen species and activation of pro-fibrotic pathways.
Can Kwiknic Pann Flav affects my liver?
Kwiknic Pann Flav has not been associated with liver test abnormalities or with clinically apparent hepatotoxicity.
Will Kwiknic Pann Flav affect my fertility?
Kwiknic Pann Flav decreased sperm quality with lower counts (numbers of sperm) and motility (sperm's ability to move) and increased numbers of abnormallyshaped sperm. Smoking might also decrease the sperm's ability to fertilize eggs.
