L-Аспарагиназа

L-Аспарагиназа Uses, Dosage, Side Effects, Food Interaction and all others data.

Trade Name	L-Аспарагиназа
Availability	Prescription only
Generic	Asparaginase
Related Drugs	prednisone, methotrexate, cyclophosphamide, Deltasone, vincristine, Cytoxan
Type
Therapeutic Class
Manufacturer
Available Country	Russia
Last Updated:	September 19, 2023 at 7:00 am

L-Аспарагиназа Alcohol interaction

[Moderate]

Concomitant use of asparaginase with other hepatotoxic agents may potentiate the risk of liver injury.

L-Аспарагиназа-associated hepatotoxicity has been reported more commonly in adults than in children and has been strongly associated with obesity.

Hepatomegaly, acute severe hepatotoxicity, and fatal liver failure have been reported with asparaginase treatment in adults.

Also, asparaginase may increase the toxicity of drugs bound to plasma proteins or metabolized by the liver.

The risk of additive hepatotoxicity should be considered when asparaginase is used with other hepatotoxic agents (e.g., alcohol, androgens, antituberculosis agents, azole antifungal agents, ACE inhibitors, macrolide antibiotics, nonsteroidal anti-inflammatory agents, nucleoside reverse transcriptase inhibitors, sulfonamides, thiazolidinediones, and statins).

Liver function tests should be monitored at regular intervals during asparaginase treatment with or without other hepatotoxic drugs.

Patients should be advised to seek medical attention if they experience potential symptoms of hepatotoxicity such as right upper quadrant pain, increasing abdominal size, fever, rash, itching, anorexia, nausea, vomiting, fatigue, malaise, dark urine, pale stools, and jaundice.