L Cart

L Cart Uses, Dosage, Side Effects, Food Interaction and all others data.

Tocopherol exists in four different forms designated as α, β, δ, and γ. They present strong antioxidant activities, and it is determined as the major form of vitamin E. Tocopherol, as a group, is composed of soluble phenolic compounds that consist of a chromanol ring and a 16-carbon phytyl chain. The classification of the tocopherol molecules is designated depending on the number and position of the methyl substituent in the chromanol ring. The different types of tocopherol can be presented trimethylated, dimethylated or methylated in the positions 5-, 7- and 8-. When the carbons at position 5- and 7- are not methylated, they can function as electrophilic centers that can trap reactive oxygen and nitrogen species. Tocopherols can be found in the diet as part of vegetable oil such as corn, soybean, sesame, and cottonseed. It is currently under the list of substances generally recognized as safe (GRAS) in the FDA for the use of human consumption.

The antioxidant effects of tocopherol can be translated into different changes at the pharmacodynamic level. In vitro studies have shown that this antioxidant activity can produce modification in protein kinase C (PKC) which will later be translated into an inhibition of cell death. Some other derivate effects are the anti-inflammatory properties of tocopherol which can be related to the modulation of cytokines or prostaglandins, prostanoids and thromboxanes.

Zinc is an essential trace mineral, which means that it must be obtained from the diet since the body cannot make enough. Next to iron, zinc is the most abundant trace mineral in the body. Stored primarily in muscle, zinc is also found in high concentrations in red and white blood cells, the retina of the eye, bones, skin, kidneys, liver, and pancreas. Some of the symptoms of zinc deficiency include loss of appetite, poor growth, weight loss, impaired taste or smell, poor wound healing, skin abnormalities (such as acne, atopic dermatitis and psoriasis), hair loss, night blindness, hypogonadism and delayed sexual maturation, white spots on the fingernails and feelings of depression.

L Cart
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	L Cart
Generic	L Carnitine + Coenzyme Q10 + Tocopherol + Magnesium Sulphate + Zinc Sulphate Monohydrate
Weight	500mg
Type	Tablet
Therapeutic Class
Manufacturer	Medsea Healthcare Pvt Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Tocopherol can be used as a dietary supplement for patients with a deficit of vitamin E; this is mainly prescribed in the alpha form. Vitamin E deficiency is rare, and it is primarily found in premature babies of very low birth weight, patients with fat malabsorption or patients with abetalipoproteinemia.

Tocopherol, due to its antioxidant properties, is studied for its use in prevention or treatment in different complex diseases such as cancer, atherosclerosis, cardiovascular diseases, and age-related macular degeneration.

Zinc Sulphate is used for Recurrent Respiratory Tract Infections; Diarrhoea; Loss of appetite; Severe growth retardation; Deformed bone formation; Impaired immunological response; Acrodermatitis enteropathica; Parakeratatic skin lesions; Defective and delayed wound healing; Anaemia; Night blindness; Mental disturbances

L Cart is also used to associated treatment for these conditions: Vitamin E Deficiency, Skin Care

How L Cart works

Tocopherol acts as a radical scavenger. It mainly acts as an antioxidant for lipid bilayers. Tocopherol's functions depend on the H-atom donating ability, location, and movement within the membrane, as well as the efficiency in the radical recycling by some cytosolic reductants such as ascorbate. Tocopherol actions are related to the trap of radicals, and it has been shown that even in the absence of substituents in the ortho-positions, tocopherol can trap more than two radicals. The type of radicals available for tocopherol are alkyl and peroxy.

Dosage

L Cart dosage

Syrup-

Children under 10 kg: One teaspoonful 2 times daily.
Children within 10 to 30 kg: Two teaspoonful 1-3 times daily.
Adults and children over 30 kg body weight: Four teaspoonful 1-3 times daily.

Tablet-In the treatment of Diarrhoea Zinc should be given as soon as diarrhoea starts:

For infants between 2 to 6 months of age: 10 mg Zinc once daily for 10-14 days.
For children between 6 months to 5 years of age: 20 mg Zinc once daily for 10-14 days.

For other indications:

The recommended dose for children: 2 to 2.5 mg/kg/day.
Children under 10 kg: 10 mg Zinc 2 times daily.
Children within 10 to 30 kg: 20 mg Zinc 1-3 times daily.
Adults and children over 30 kg body weight: 40 mg Zinc 1-3 times daily.

Dispersible Tablet-

Place the tablet in a teaspoon
Add adequate amount of water
Let the tablet dissolve completely
Give the entire spoonful solution

Side Effects

In case of zinc mild side effects such as gastric ulcer, nausea, vomiting, metallic taste, headache, drowsiness have been observed.

Toxicity

Tocopherols are considered as non-toxic but if very high doses are administered, there are reports of hemorrhagic activity. Reproductive and developmental toxicity tests are negative. These negative results were also observed in the analysis of mutagenicity and carcinogenicity.

Precaution

Concurrent administration of Zinc salt with penicillamine might diminish the effect of Penicillamine. The absorption of Zinc, although poor, may be decreased by various compounds including some foods. Chelation may occur with tetracyclines.

Interaction

Zinc may inhibit the absorption of concurrently administered tetracyclines, when both are being given an interval of at least 3 hours.

Volume of Distribution

The apparent volume of distribution of tocopherol is approximately 0.5 ml.

Elimination Route

The absorption of tocopherol in the digestive tract requires the presence of fat. The approximate tmax of the four different isomers of tocopherol is attained in the range of 3-6 hours. When compared with tocotrienols, tocopherols showed a reduced bioavailability. The bioavailability of tocopherols is highly dependent on the type of isomer that is administered where the alpha-tocopherol can present a bioavailability of 36%. This isomer specificity also determines the intestinal permeability in which the gamma-tocopherol presents a very low permeability. After oral administration, the Cmax, AUC and mean residence time of tocopherols showed to be dependent on the isomer and ranged from 590-2915 ng/ml, 3740-10169 ng/ml and 4.85-5.74 h, respectively.

Half Life

The elimination half-life of tocopherol is approximately 2.6 hours.

Clearance

The clearance rate of tocopherol is approximately 0.15 l/h.

Elimination Route

The pharmacokinetic profile of tocopherol indicates a longer time of excretion for tocopherols when compared to tocotrienols. The different conjugated metabolites are excreted in the urine or feces depending on the length of their side-chain. Due to their polarity, intermediate-chain metabolites and short-chain metabolites are excreted via urine as glucoside conjugates. A mixture of all the metabolites and precursors can be found in feces. The long-chain metabolites correspond to >60% of the total metabolites in feces. It is estimated that the fecal excretion accounts for even 80% of the administered dose.

Pregnancy & Breastfeeding use

Pregnant women and nursing mothers should avoid zinc doses higher than RDA amounts.

Contraindication

It is contraindicated in patients with hypersensitivity to Zinc.

Acute Overdose

Zinc sulphate is corrosive in overdose. Symptoms are corrosion and inflammation of the mucous membrane of the mouth and stomach; ulceration of the stomach followed by perforation may occur. Gastric lavage and emesis should be avoided. Demulcents such as milk should be given. Chelating agents such as sodium edetate may be useful.