Lacasil

Lacasil Uses, Dosage, Side Effects, Food Interaction and all others data.

In the colon it is broken down to short chain organic acids and increases osmotic pressure in the colon, thereby causing an increase in the stool water content and stool volume.

Lacasil helps to facilitate bowel movements by drawing water into the gastrointestinal tract. The oral administration of lactitol may reduce the absorption of concomitant medications - other oral medications should be administered at least 2 hours before or 2 hours after lactitol.

Lacasil
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Lacasil
Availability	Prescription only
Generic	Lactitol
Lactitol Other Names	Lactitol, Lactitolum
Related Drugs	Trulance, Motegrity, prucalopride, plecanatide, Pizensy
Weight	3.35g/5ml
Type	Syrup
Formula	C₁₂H₂₄O₁₁
Weight	Average: 344.3124 Monoisotopic: 344.13186161
Protein binding	As it undergoes little-to-no systemic absorption, lactitol is unlikely to be subject to protein binding.
Groups	Approved, Investigational
Therapeutic Class	Osmotic purgatives
Manufacturer	Sami Pharmaceuticals (pvt) Ltd,
Available Country	Pakistan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Constipation, Hepatic encephalopathy

Lacasil is also used to associated treatment for these conditions: Constipation, Hepatic Encephalopathy (HE), Occasional Constipation, Chronic idiopathic constipation (CIC)

How Lacasil works

Lacasil is an osmotic laxative - it exerts its pharmacologic effect by creating a hyperosmotic environment within the small intestine. The osmotic effect generated by lactitol draws water into the small intestine, which loosens stools and ultimately facilitates bowel movements.

Dosage

Lacasil dosage

2 teaspoonfuls (20 gm) once or twice daily with plenty of water

Side Effects

Abdominal distension, flatulance and abdominal cramp.

Toxicity

The LD₅₀ is 23 g/kg in mice and >30 g/kg in rats.

Experience with acute overdosage is limited, but is likely to involve significant gastrointestinal upset and diarrhea consistent with the pharmacologic profile of lactitol. Overdosage should be managed with symptomatic and supportive measures, where necessary.

Precaution

Lactose intolerance.

Food Interaction

Take with food. The manufacturer recommends administration with meals.

[Moderate] ADJUST DOSING INTERVAL: Lacasil may decrease the absorption of concomitantly administered oral medications.

MANAGEMENT: Lacasil should be administered at least 2 hours before or 2 hours after concomitant oral medications.

Lacasil Drug Interaction

Unknown: tamsulosin, magaldrate / simethicone, magnesium hydroxide, acetaminophen, senna, docusate/senna, cholecalciferol, bifidobacterium infantis / lactobacillus acidophilus / streptococcus thermophilus

Volume of Distribution

Data regarding the volume of distribution of lactitol are unavailable.

Elimination Route

In healthy subjects under fed conditions, oral administration of 20 grams of lactitol resulted in a mean T_max of 3.6 ± 1.2 hours, C_max of 776 ± 253 ng/mL, and a mean AUC of 6,019 ± 1,771 ng*hr/mL.

Half Life

The average half-life of orally administered lactitol is 2.4 hours.

Clearance

Data regarding the clearance of lactitol are unavailable.

Elimination Route

Lacasil is not absorbed in the gastrointestinal tract to any significant extent. The vast majority of an ingested dose is likely degraded into organic acids in the colon and eliminated in the feces.