Lacrelax

Lacrelax Uses, Dosage, Side Effects, Food Interaction and all others data.

A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads to excretion of these amino acids and a decrease in ammonia levels. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia. Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo.

In the colon it is broken down to short chain organic acids and increases osmotic pressure in the colon, thereby causing an increase in the stool water content and stool volume.

Lactitol helps to facilitate bowel movements by drawing water into the gastrointestinal tract. The oral administration of lactitol may reduce the absorption of concomitant medications - other oral medications should be administered at least 2 hours before or 2 hours after lactitol.

Lacrelax
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Lacrelax
Generic	Lactitol + Benzoic Acid
Type	Syrup
Therapeutic Class
Manufacturer	Tirupati Lifesciences Pvt Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Benzoic acid is an antimicrobial food additive.

Constipation, Hepatic encephalopathy

Lacrelax is also used to associated treatment for these conditions: Infections, Fungal, Oropharyngeal pain, Pain, Ringworm, Sore Throat, Tinea Pedis, Burning sensation in the mouth, Dry cough, Mouth infection, Throat infectionsConstipation, Hepatic Encephalopathy (HE), Occasional Constipation, Chronic idiopathic constipation (CIC)

How Lacrelax works

Lactitol is an osmotic laxative - it exerts its pharmacologic effect by creating a hyperosmotic environment within the small intestine. The osmotic effect generated by lactitol draws water into the small intestine, which loosens stools and ultimately facilitates bowel movements.

Dosage

Lacrelax dosage

2 teaspoonfuls (20 gm) once or twice daily with plenty of water

Side Effects

Abdominal distension, flatulance and abdominal cramp.

Toxicity

The LD₅₀ is 23 g/kg in mice and >30 g/kg in rats.

Experience with acute overdosage is limited, but is likely to involve significant gastrointestinal upset and diarrhea consistent with the pharmacologic profile of lactitol. Overdosage should be managed with symptomatic and supportive measures, where necessary.

Precaution

Lactose intolerance.

Volume of Distribution

Data regarding the volume of distribution of lactitol are unavailable.

Elimination Route

In healthy subjects under fed conditions, oral administration of 20 grams of lactitol resulted in a mean T_max of 3.6 ± 1.2 hours, C_max of 776 ± 253 ng/mL, and a mean AUC of 6,019 ± 1,771 ng*hr/mL.

Half Life

The average half-life of orally administered lactitol is 2.4 hours.

Clearance

Data regarding the clearance of lactitol are unavailable.

Elimination Route

Lactitol is not absorbed in the gastrointestinal tract to any significant extent. The vast majority of an ingested dose is likely degraded into organic acids in the colon and eliminated in the feces.