Lacrin Ophthalmic Solution 0.5%+0.9%

Lacrin Ophthalmic Solution 0.5%+0.9% Uses, Dosage, Side Effects, Food Interaction and all others data.

Each ml of Carboxymethylcellulose Sodium sterile eye gel drops contains: Active Substance: Carboxymethylcellulose Sodium USP 10 mg. Preservative: Purite 0.0075%

Glycerin is a hyperosmotic laxative, given rectally, which usually produces a bowel movement within 15 minutes to 1 hour. Hyperosmotic laxatives encourage bowel movements by drawing water into the bowel from surrounding tissues. This produces a softer stool mass and increased bowel action. These products are used for fast, predictable relief of occasional constipation.

Glycerin is commonly classified as an osmotic laxative but may act additionally or alternatively through its local irritant effects; it may also have lubricating and fecal softening actions. Glycerin suppositories usually work within 15 to 30 minutes.

Lacrin Ophthalmic Solution 0.5%+0.9%
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Lacrin Ophthalmic Solution 0.5%+0.9%
Generic	Carboxymethylcellulose Sodium + Glycerin
Weight	0.5%+0.9%
Type	Ophthalmic Solution
Therapeutic Class	Drugs for Dry eyes
Manufacturer	OSL Pharma Limited
Available Country	Bangladesh
Last Updated:	October 19, 2023 at 6:27 am

Uses

This Sterile Eye Drops is indicated for the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun.

Lacrin Ophthalmic Solution 0.5%+0.9% is also used to associated treatment for these conditions: Cold Sore, Constipation, Dry Mouth, Dry Skin, Dry throat, Edema of the cerebrum, Hypertension Intracranial, Occasional Constipation, Ocular Discomfort, Ocular Hypertension, Ocular Irritation, Skin Infections, Sore Throat, Mouth soreness, Ocular burning, Bowel preparation therapy, Topical Antisepsis, Skin protection

How Lacrin Ophthalmic Solution 0.5%+0.9% works

When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Glycerin decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.

Dosage

Lacrin Ophthalmic Solution 0.5%+0.9% dosage

Instill 1 drop in the affected eyes as needed.It can be used in children.

Side Effects

Vision may be temporarily blurred when this product is first used. Also, minor burning/ stinging/ irritation may temporarily occur.

Toxicity

Glycerol has very low toxicity when ingested ; Rat LD50 (oral)-12600mg/kg Mice LD50 (oral )-4090mg/kg Human TDLo (oral) - 1428mg/kg

Precaution

Consult doctor if irritation, eye pain or visual changes worsen or persist beyond 72 hours.

Interaction

If several medicines are to be administered to the eye, there should be an interval of at least 5 minutes between each application.

Volume of Distribution

Glycerin is distributed throughout the blood. Although glycerin generally does not appear in ocular fluids, it may enter the orbital sac when the eye is inflamed, with a consequent decrease in osmotic effect.

Elimination Route

Well absorbed orally, poorly absorbed rectally. Studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach

Half Life

30 - 45 minutes

Elimination Route

Approx 7-14% of dose is excreted unchanged in the urine within 2.5 hr.

Pregnancy & Breastfeeding use

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Carboxymethylcellulose Sodium and Glycerin should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.Use in lactation: Carboxymethylcellulose Sodium or Glycerin has not been measured in human milk. Caution should be exercised when the combination of Carboxymethylcellulose Sodium and Glycerin is administered to a nursing mother.

Contraindication

It is contraindicated in patients with known hypersensitivity to any ingredient of this formulation.

Special Warning

Pediatric use: This eye drop should not be used in infants and small children under 3 years.Geriatric use: No overall differences in safety or effectiveness have been observed between elderly and other adult patients.