Lactigol

Lactigol Uses, Dosage, Side Effects, Food Interaction and all others data.

The husk and seed of Plantago ovata are commonly known as psyllium or Ispaghula. Psyllium is widely used as a fiber supplement for the treatment of constipation. Psyllium husk is obtained by milling the seed of P.ovata.Psyllium is classified as a mucilaginous fiber due to its powerful ability to form a gel in water. This ability comes from its role as the endosperm of the P. ovata seed, where it's functions to retain water in order to prevent the seed from drying out. Psyllium husk contains

High proportion of hemicelluloseArabinoseRhamnoseGalacturonic acid units (arabinoxylans)35% soluble and 65% insoluble polysaccharidesMost of the Ispaghula reach the caecum within four hours after ingestion in an intact and highly polymerized form. Ispaghula husk significantly increases the level of stool moisture, as well as wet and dry stool weight and shorten gastrointestinal transit time. Anaerobic fermentation of the soluble non-starch polysaccharides from Ispaghula seed results in the production of short chain fatty acids, acetate, propionate and butyrate in the intestine. Butyric acid is the preferred oxidative substrate for colonocytes and may be helpful in the treatment of ulcerative colitis. Ispaghula has hypocholesterolemic effects also. It is assumed that Ispaghula increases the activity of cholesterol alpha hydroxylase, HMG-CoA reductase and fractional turnover of both chenodeoxycholic and cholic acids. As a result it decreases cholesterol absorption and lowers LDL cholesterol.

HighproportionofhemicelluloseArabinoseRhamnoseGalacturonicacidunits(arabinoxylans)35%solubleand65%insolublepolysaccharidesMostoftheIspaghulareachthecaecumwithinfourhoursafteringestioninanintactandhighlypolymerizedform.Ispaghulahusksignificantlyincreasesthelevelofstoolmoisture,aswellaswetanddrystoolweightandshortengastrointestinaltransittime.Anaerobicfermentationofthesolublenon-starchpolysaccharidesfromIspaghulaseedresultsintheproductionofshortchainfattyacids,acetate,propionateandbutyrateintheintestine.Butyricacidisthepreferredoxidativesubstrateforcolonocytesandmaybehelpfulinthetreatmentofulcerativecolitis.Ispaghulahashypocholesterolemiceffectsalso.ItisassumedthatIspaghulaincreasestheactivityofcholesterolalphahydroxylase,HMG-CoAreductaseandfractionalturnoverofbothchenodeoxycholicandcholicacids.AsaresultitdecreasescholesterolabsorptionandlowersLDLcholesterol.

In the colon it is broken down to short chain organic acids and increases osmotic pressure in the colon, thereby causing an increase in the stool water content and stool volume.

Lactitol helps to facilitate bowel movements by drawing water into the gastrointestinal tract. The oral administration of lactitol may reduce the absorption of concomitant medications - other oral medications should be administered at least 2 hours before or 2 hours after lactitol.

Lactigol
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Lactigol
Generic	Lactitol + Ispaghula Husk
Weight	10gm
Type	Granules
Therapeutic Class
Manufacturer	Lupin
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

This medicine contains ispaghula husk which is a bulking agent. This means that when it is taken with water it increases the size of the faeces (stools) and helps solid waste to pass through the body. Ispaghula Husk sachets are used to treat constipation and in conditions where it is better for the patient to have soft stools. They are also used for patients who require a high fibre diet

Constipation, Hepatic encephalopathy

Lactigol is also used to associated treatment for these conditions: Constipation, Hepatic Encephalopathy (HE), Occasional Constipation, Chronic idiopathic constipation (CIC)

How Lactigol works

Lactitol is an osmotic laxative - it exerts its pharmacologic effect by creating a hyperosmotic environment within the small intestine. The osmotic effect generated by lactitol draws water into the small intestine, which loosens stools and ultimately facilitates bowel movements.

Dosage

Lactigol dosage

Constipation:

Adult: 3.5 g 1-3 times daily. Mix with a full glass of liq.
Child: ≤12 yr Each level 5-mL spoonful contains 1.75 g: Half to 1 level 5-mL spoonful bid (morning and evening) to be dissolved in water.

Mild to moderate hypercholesterolaemia:

Adult: As adjunct to lipid-lowering diet: 7.5-10 g daily. Mix with a full glass of liq.

2 teaspoonfuls (20 gm) once or twice daily with plenty of water

Should be taken on an empty stomach. Take before meals with a full glass of water.

Side Effects

Abdominal distention, flatulence, GI impaction, GI obstruction, hypersensitivity reactions e.g. rhinitis, conjunctivitis, bronchospasm and anaphylaxia; cutaneous symptoms (e.g. exanthema and/or pruritus).

Abdominal distension, flatulance and abdominal cramp.

Toxicity

The LD₅₀ is 23 g/kg in mice and >30 g/kg in rats.

Experience with acute overdosage is limited, but is likely to involve significant gastrointestinal upset and diarrhea consistent with the pharmacologic profile of lactitol. Overdosage should be managed with symptomatic and supportive measures, where necessary.

Precaution

Patient with swallowing difficulty. Children.

Lactose intolerance.

Interaction

Concurrent use of licorice, laxatives and antidiabetic agents may result in increased risk of hypokalemia and hypoglycemia. Carbamazepine bio-availability may be reduced during concomitant administration of psyllium seed.

Volume of Distribution

Data regarding the volume of distribution of lactitol are unavailable.

Elimination Route

In healthy subjects under fed conditions, oral administration of 20 grams of lactitol resulted in a mean T_max of 3.6 ± 1.2 hours, C_max of 776 ± 253 ng/mL, and a mean AUC of 6,019 ± 1,771 ng*hr/mL.

Half Life

The average half-life of orally administered lactitol is 2.4 hours.

Clearance

Data regarding the clearance of lactitol are unavailable.

Elimination Route

Lactitol is not absorbed in the gastrointestinal tract to any significant extent. The vast majority of an ingested dose is likely degraded into organic acids in the colon and eliminated in the feces.