Laispeg Granules
Laispeg Granules Uses, Dosage, Side Effects, Food Interaction and all others data.
In the colon it is broken down to short chain organic acids and increases osmotic pressure in the colon, thereby causing an increase in the stool water content and stool volume.
Laispeg Granules helps to facilitate bowel movements by drawing water into the gastrointestinal tract. The oral administration of lactitol may reduce the absorption of concomitant medications - other oral medications should be administered at least 2 hours before or 2 hours after lactitol.
Trade Name | Laispeg Granules |
Availability | Prescription only |
Generic | Lactitol |
Lactitol Other Names | Lactitol, Lactitolum |
Related Drugs | Trulance, Motegrity, prucalopride, plecanatide, Pizensy |
Type | |
Formula | C12H24O11 |
Weight | Average: 344.3124 Monoisotopic: 344.13186161 |
Protein binding | As it undergoes little-to-no systemic absorption, lactitol is unlikely to be subject to protein binding. |
Groups | Approved, Investigational |
Therapeutic Class | Osmotic purgatives |
Manufacturer | Fourrts India Laboratories Pvt Ltd |
Available Country | India |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Constipation, Hepatic encephalopathy
Laispeg Granules is also used to associated treatment for these conditions: Constipation, Hepatic Encephalopathy (HE), Occasional Constipation, Chronic idiopathic constipation (CIC)
How Laispeg Granules works
Laispeg Granules is an osmotic laxative - it exerts its pharmacologic effect by creating a hyperosmotic environment within the small intestine. The osmotic effect generated by lactitol draws water into the small intestine, which loosens stools and ultimately facilitates bowel movements.
Dosage
Laispeg Granules dosage
2 teaspoonfuls (20 gm) once or twice daily with plenty of water
Side Effects
Abdominal distension, flatulance and abdominal cramp.
Toxicity
The LD50 is 23 g/kg in mice and >30 g/kg in rats.
Experience with acute overdosage is limited, but is likely to involve significant gastrointestinal upset and diarrhea consistent with the pharmacologic profile of lactitol. Overdosage should be managed with symptomatic and supportive measures, where necessary.
Precaution
Lactose intolerance.
Food Interaction
- Take with food. The manufacturer recommends administration with meals.
[Moderate] ADJUST DOSING INTERVAL: Laispeg Granules may decrease the absorption of concomitantly administered oral medications.
MANAGEMENT: Laispeg Granules should be administered at least 2 hours before or 2 hours after concomitant oral medications.
Laispeg Granules Drug Interaction
Unknown: tamsulosin, magaldrate / simethicone, magnesium hydroxide, acetaminophen, senna, docusate/senna, cholecalciferol, bifidobacterium infantis / lactobacillus acidophilus / streptococcus thermophilus
Volume of Distribution
Data regarding the volume of distribution of lactitol are unavailable.
Elimination Route
In healthy subjects under fed conditions, oral administration of 20 grams of lactitol resulted in a mean Tmax of 3.6 ± 1.2 hours, Cmax of 776 ± 253 ng/mL, and a mean AUC of 6,019 ± 1,771 ng*hr/mL.
Half Life
The average half-life of orally administered lactitol is 2.4 hours.
Clearance
Data regarding the clearance of lactitol are unavailable.
Elimination Route
Laispeg Granules is not absorbed in the gastrointestinal tract to any significant extent. The vast majority of an ingested dose is likely degraded into organic acids in the colon and eliminated in the feces.
Pregnancy & Breastfeeding use
Pregnancy Category - Not Classified. FDA has not yet classified the drug into a specified pregnancy category.
Contraindication
Patients with known hypersensitivity to any of the active substance. Gastro-intestinal obstruction. Galactosaemia.
Innovators Monograph
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