Lamocard Tablet 5 mg

Lamocard Tablet 5 mg Uses, Dosage, Side Effects, Food Interaction and all others data.

Trade Name Lamocard Tablet 5 mg
Generic Levamlodipine Maleate
Weight 5 mg
Type Tablet
Therapeutic Class Calcium-channel blockers
Manufacturer Drug International Ltd.
Available Country Bangladesh
Last Updated: October 19, 2023 at 6:27 am
Lamocard Tablet 5 mg
Lamocard Tablet 5 mg

Uses

Levamlodipine is calcium channel blocker and may be used alone or in combination with other antihypertensive agents for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.

Dosage

Lamocard Tablet 5 mg dosage

Route of administration: Should be taken orally.Dosage: The usual initial antihypertensive oral dose of Levamlodipine is 2.5 mg once daily, and the maximum dose is 5 mg once daily.Adult and elderly patients: Elderly patients, or patients with hepatic insufficiency may be started on 1.25 mg once daily and this dose may be used when adding Levamlodipine to other antihypertensive therapy. Dosage needs to be adjusted according to blood pressure goals. 7 to 14 days waiting period between titration steps is needed. Titration needs to be done more rapidly, however, if clinically warranted, provided the patient is assessed frequently. Use in children and adolescents: The effective antihypertensive oral dose in pediatric patients ages 6-17 years is 1.25 mg to 2.5 mg once daily. Doses in excess of 2.5 mg daily have not been studied in pediatric patients.

Side Effects

Common: Difficulty in breathing, Dizziness, Reflex Tachycardia, Hypotension, Abdominal Pain & Edema.Rare: Diarrhea, Back pain, Headache, Fatigue & Nausea.

Precaution

Hypotension: Symptomatic hypotension is possible, particularly in patients with severe aortic stenosis. Because of the gradual onset of action, acute hypotension is unlikely.Increased Angina or Myocardial Infarction: Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of amlodipine, particularly in patients with severe obstructive coronary artery disease.Patients with Hepatic Failure: Because amlodipine is extensively metabolized by the liver and the plasma elimination half-life (t½) is 56 hours in patients with impaired hepatic function, titrate slowly when administering amlodipine to patients with severe hepatic impairment.

Interaction

Impact of other drugs on Amlodipine: CYP3A Inhibitors: Co-administration with CYP3A inhibitors (moderate and strong) results in increased systemic exposure to amlodipine and may require dose reduction. CYP3A Inducers: No information is available on the quantitative effects of CYP3A inducers on amlodipine. Impact of Amlodipine on other drugs: Simvastatin: Co-administration of simvastatin with amlodipine increases the systemic exposure of simvastatin. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily. Immunosuppressants: Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when co-administered. Frequent monitoring of trough blood levels of cyclosporine and tacrolimus is recommended and adjust the dose when appropriate. With food and others: Can be taken with or without food. The absorption is unaffected by food. Avoid grapefruit products & natural licorice.

Pregnancy & Breastfeeding use

The limited available data based on post-marketing reports with amlodipine use in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage. No adverse effects of amlodipine on the breastfed infant have been observed.

Contraindication

S-Amlodipine is contraindicated in patients with known sensitivity to amlodipine.

Acute Overdose

Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia.

Storage Condition

Store in a cool & dry place, protect from light & moisture. Keep all medicines out of reach of children.

Innovators Monograph

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