Laronidase

Laronidase Uses, Dosage, Side Effects, Food Interaction and all others data.

Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.

Laronidase is used to treat mucopolysaccharide storage disorders (specifically mucopolysaccharidosis 1 or Hurlers syndrome) caused by deficiencies of alpha-L-iduronidase. Reduced or absent a-L-iduronidase activity results in the accumulation of the GAG substrates, dermatan sulfate and heparan sulfate, throughout the body and leads to widespread cellular, tissue, and organ dysfunction.

Trade Name Laronidase
Availability Prescription only
Generic Laronidase
Laronidase Other Names alpha-L-Idosiduronase, Human Recombinant alpha-L-iduronidase, Laronidasa, Laronidase, Laronidase (genetical recombination)
Related Drugs Aldurazyme
Weight 2.9mg/5ml,
Type Intravenous Solution, Intravenous
Formula C3160H4848N898O881S12
Weight 69899.4 Da
Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Laronidase
Laronidase

Uses

Laronidase is a form of recombinant human alpha-L-iduronidase used to treat Hurler and Hurler-Scheie forms of mucopolysaccharidosis, a genetic deficiency of alpha-L-iduronidase.

For the treatment of mucopolysaccharidosis

Laronidase is also used to associated treatment for these conditions: Type 1 Mucopolysaccharidosis

How Laronidase works

Laronidase catalyses the hydrolysis of terminal alpha-L-iduronic acid residues of dermatan sulfate and heparin sulfate.

Food Interaction

No interactions found.

Laronidase Disease Interaction

Major: hypersensitivity

Half Life

1.5-3.6 hrs

Innovators Monograph

You find simplified version here Laronidase

*** Taking medicines without doctor's advice can cause long-term problems.
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