Laxacos

Laxacos Uses, Dosage, Side Effects, Food Interaction and all others data.

Laxacos is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been used in European countries for many years .

Sodium picosulfate is a stimulant laxative that in conjunction with magnesium citrate, produces a purgative effect on stools. In a multicentre, observational study comprising of patients undergoing colonoscopy, more than 93.0% of the patients receiving sodium picosulfate-containing preparations reported the colon cleansing effect to be effective .

Trade Name Laxacos
Generic Picosulfuric acid
Picosulfuric acid Other Names Picosulfate, Picosulphate
Weight 5mg/5ml
Type Syrup
Formula C18H15NO8S2
Weight Average: 437.44
Monoisotopic: 437.023908795
Protein binding

No pharmacokinetic data is available for picosulfuric acid.

Groups Approved
Therapeutic Class
Manufacturer Bio Labs (pvt) Ltd,
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Laxacos
Laxacos

Uses

Laxacos is a stimulant laxative used for cleansing of the colon as a preparation for colonoscopy in adults.

Indicated for cleansing of the colon as a preparation for colonoscopy in adults .

Laxacos is also used to associated treatment for these conditions: Constipation, Bowel preparation therapy, Laxative

How Laxacos works

Laxacos, as sodium picosulfate, is a contact laxative. Sodium picosulfate inhibits the absorption of water and electrolytes, and increases their secretion into the intestinal lumen . It is hydrolyzed by colonic bacterial enzyme, sulfatase , to form an active metabolite bis-(p-hydroxy-phenyl)-pyridyl-2-methane (BHPM), which acts directly on the colonic mucosa to stimulate colonic peristalsis .

Toxicity

Overdosage of laxative preparations containing sodium picosulfate may lead to severe electrolyte disturbances, in addition to dehydration and hypovolemia, with signs and symptoms of these disturbances. In case of overdose, monitor for fluid and electrolyte disturbances with symptomatic treatment . In vitro, 800 and 1600 mg/mL of sodium picosulfate exerted cytotoxic effects on cultured liver cells by inducing dose-dependent vacuolic and fatty change, as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit .

Food Interaction

  • Avoid alcohol.
  • Avoid solid foods. When using picosulfuric acid in preparation for a colonoscopy, only consume clear fluids the day before the procedure.

Volume of Distribution

No pharmacokinetic data is available for picosulfuric acid.

Elimination Route

In healthy volunteers receiving 2 packets of sodium picosulfate in combination with magnesium oxide and anhydrous citric acid every 6 hours, the mean peak plasma concentrations (Cmax) of sodium picosulfate was achieved within 7 hours (Tmax) . The mean Cmax of its active metabolite, BHPM, was 0.05 ng/mL .

Half Life

The terminal half-life of sodium picosulfate was 7.4 hours .

Clearance

No pharmacokinetic data is available for picosulfuric acid.

Elimination Route

Sodium picosulfate and its metabolite BHPM are mainly excreted in urine. The fraction of the absorbed sodium picosulfate dose excreted in urine as unchanged parent compound was 0.19% . Urinary recovery of BHPM was 0.01% of total administered drug . A small amount absorbed picosulfate is reported to be excreted in the urine as a glucuronide-conjugate of BHPM .

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*** Taking medicines without doctor's advice can cause long-term problems.
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