Lecerein Gm

Lecerein Gm Uses, Dosage, Side Effects, Food Interaction and all others data.

Diacerein is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.

Decreases inflammation and cartilage destruction and also corrects altered osteoblast acitivity .

Lecerein Gm
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Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Trade Name	Lecerein Gm
Generic	Glucosamine Sulfate + Diacerein + Methylsulfonylmethane
Weight	50mg
Type	Tablet
Therapeutic Class
Manufacturer	Lexus India Organics
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Diacerein is an slow-onset anthraquinone IL-1 inhibitor used in the treatment of degenerative joint diseases like osteoarthritis.

For the treatment of osteoarthritis affecting the hip or knee .

Lecerein Gm is also used to associated treatment for these conditions: Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee

How Lecerein Gm works

Diacerein's active metabolite rhein Rhein reduces cartilage destruction by decreasing expression of matrix metalloproteinase (MMP)-1 and -3 as well as upregulating tissue inhibitor of matrix metalloproteinases which serve to reduce the activity of several MMPs . The anti-inflammatory action of rhein reduces the level of interleukin-1beta activity which plays a large role in reduction of extracellular matrix production, MMP activity, and continued inflammation . Rhein reduces abnormal osteoblast synthetic activity through an unknown mechanism .