Leucenol

Leucenol Uses, Dosage, Side Effects, Food Interaction and all others data.

Leucenol is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.

Leucenol inhibits DNA synthesis at the level of elongation of nascent chains by altering deoxyribonucleotide metabolism. It arrests the cell cycle in the late G(1) phase.

Trade Name	Leucenol
Generic	Mimosine
Mimosine Other Names	L-Mimosine, Leucaenine, Leucaenol, Leucenine, Leucenol, Mimosin
Type
Formula	C8H10N2O4
Weight	Average: 198.176 Monoisotopic: 198.064056818
Protein binding	>99.5%
Groups	Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

How Leucenol works

Leucenol causes inhibition of DNA replication, changes in the progression of the cells in the cell cycle, and apoptosis. Leucenol appears to introduce breaks into DNA. Leucenol is an iron/zinc chelator. Iron depletion induces DNA double-strand breaks in treated cells, and activates a DNA damage response that results in focal phosphorylation of histones. This leads to inhibition of DNA replication and/or DNA elongation. Some studies indicate that mimosine prevents the initiation of DNA replication, whereas other studies indicate that mimosine disrupts elongation of the replication fork by impairing deoxyribonucleotide synthesis by inhibiting the activity of the iron-dependent enzyme ribonucleotide reductase and the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT). Inhibition of serine hydroxymethyltransferase is moderated by a zinc responsive unit located in front of the SHMT gene.

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