Leucomax (DRUGS USED IN DIABETES)

Leucomax (DRUGS USED IN DIABETES) Uses, Dosage, Side Effects, Food Interaction and all others data.

Leucomax (DRUGS USED IN DIABETES) is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.

Leucomax (DRUGS USED IN DIABETES) is used in the treatment of bone marrow transplant recipients or those exposed to chemotherapy an recovering from acut myelogenous leukemia, Leukine or GM-CSF is a hematopoietic growth factor which stimulates the survival, clonal expansion (proliferation) and differentiation of hematopoietic progenitor cells. GM-CSF is also capable of activating mature granulocytes and macrophages. After a bone marrow transplant or chemotherapy, patients have a reduced capacity to produce red and white blood cells. Supplementing them with external sources of GM-CSF helps bring the level of neutrophils back to normal so that they can better fight infections.

Table Of contents

• Leucomax (DRUGS USED IN DIABETES)
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Leucomax (DRUGS USED IN DIABETES)
Availability	Prescription only
Generic	Sargramostim
Sargramostim Other Names	rGM-CSF, rHu GM-CSF, Sargramostim
Related Drugs	fluconazole, Diflucan, cisplatin, Neulasta, Promacta, filgrastim, Zarxio, Neupogen, pegfilgrastim, eltrombopag
Type
Formula	C639H1006N168O196S8
Weight	14434.5 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	Bahrain
Last Updated:	September 19, 2023 at 7:00 am

Uses

Leucomax (DRUGS USED IN DIABETES) is a modified form of recombinant human granulocyte-macrophage colony stimulating factor used to increase immune cell production after myelosuppressive therapy or bone marrow transplant.

For the treatment of cancer and bone marrow transplant

Leucomax (DRUGS USED IN DIABETES) is also used to associated treatment for these conditions: Bone Marrow Suppression, Delayed engraftment, Graft Failure, Neutropenia, Mobilization of hematopoietic progenitor cells into peripheral blood for collection by leukapheresis therapy

How Leucomax (DRUGS USED IN DIABETES) works

Leucomax (DRUGS USED IN DIABETES) binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils

Food Interaction

No interactions found.

Leucomax (DRUGS USED IN DIABETES) Drug Interaction

Unknown: amphotericin b lipid complex, isotretinoin, tocilizumab, corticotropin, alteplase, loxapine, fluticasone / salmeterol, theophylline, ketotifen ophthalmic, aluminum hydroxide, testosterone, umeclidinium / vilanterol, dolasetron, hydralazine, mesalamine, ethinyl estradiol / norethindrone, darbepoetin alfa, leflunomide, donepezil, benazepril

Leucomax (DRUGS USED IN DIABETES) Disease Interaction

Major: arrhythmia, fluid retention, hepatic dysfunction, leukocytosis, myeloid tumors, prematurity, renal dysfunction, respiratory symptoms

Clearance

• 420 mL/min/m2 [Normal people with liquid LEUKINE (IV)]
• 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)]
• 549 mL/min/m2 [Normal people with liquid LEUKINE (SC)]
• 529 mL/min/m2 [Normal people with lyophilized LEUKINE (SC)]

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