Leucomax (DRUGS USED IN DIABETES) Uses, Dosage, Side Effects and more
Leucomax (DRUGS USED IN DIABETES) is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Leucomax (DRUGS USED IN DIABETES) is used in the treatment of bone marrow transplant recipients or those exposed to chemotherapy an recovering from acut myelogenous leukemia, Leukine or GM-CSF is a hematopoietic growth factor which stimulates the survival, clonal expansion (proliferation) and differentiation of hematopoietic progenitor cells. GM-CSF is also capable of activating mature granulocytes and macrophages. After a bone marrow transplant or chemotherapy, patients have a reduced capacity to produce red and white blood cells. Supplementing them with external sources of GM-CSF helps bring the level of neutrophils back to normal so that they can better fight infections.
| Trade Name | Leucomax (DRUGS USED IN DIABETES) |
| Availability | Prescription only |
| Generic | Sargramostim |
| Sargramostim Other Names | rGM-CSF, rHu GM-CSF, Sargramostim |
| Related Drugs | fluconazole, Diflucan, cisplatin, Neulasta, Promacta, filgrastim, Zarxio, Neupogen, pegfilgrastim, eltrombopag |
| Type | |
| Formula | C639H1006N168O196S8 |
| Weight | 14434.5 Da |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Bahrain |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Leucomax (DRUGS USED IN DIABETES) is a modified form of recombinant human granulocyte-macrophage colony stimulating factor used to increase immune cell production after myelosuppressive therapy or bone marrow transplant.
For the treatment of cancer and bone marrow transplant
Leucomax (DRUGS USED IN DIABETES) is also used to associated treatment for these conditions: Bone Marrow Suppression, Delayed engraftment, Graft Failure, Neutropenia, Mobilization of hematopoietic progenitor cells into peripheral blood for collection by leukapheresis therapy
How Leucomax (DRUGS USED IN DIABETES) works
Leucomax (DRUGS USED IN DIABETES) binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils
Food Interaction
No interactions found.Leucomax (DRUGS USED IN DIABETES) Drug Interaction
Unknown: amphotericin b lipid complex, isotretinoin, tocilizumab, corticotropin, alteplase, loxapine, fluticasone / salmeterol, theophylline, ketotifen ophthalmic, aluminum hydroxide, testosterone, umeclidinium / vilanterol, dolasetron, hydralazine, mesalamine, ethinyl estradiol / norethindrone, darbepoetin alfa, leflunomide, donepezil, benazepril
Leucomax (DRUGS USED IN DIABETES) Disease Interaction
Major: arrhythmia, fluid retention, hepatic dysfunction, leukocytosis, myeloid tumors, prematurity, renal dysfunction, respiratory symptoms
Clearance
- 420 mL/min/m2 [Normal people with liquid LEUKINE (IV)]
- 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)]
- 549 mL/min/m2 [Normal people with liquid LEUKINE (SC)]
- 529 mL/min/m2 [Normal people with lyophilized LEUKINE (SC)]
