Levobetaxolol
Levobetaxolol Uses, Dosage, Side Effects, Food Interaction and all others data.
Levobetaxolol is a beta-blocker used to lower the pressure in the eye to treat conditions such as glaucoma. It was marketed as a 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon but has been discontinued.
Levobetaxolol is a selective β1 adrenergic receptor antagonist . It acts to lower intraocular pressure. Levobataxolol is condsidered to be the more active component of the betaxolol racemate.
| Trade Name | Levobetaxolol |
| Generic | Levobetaxolol |
| Levobetaxolol Other Names | (S)-betaxolol, Levobetaxolol |
| Type | |
| Formula | C18H29NO3 |
| Weight | Average: 307.434 Monoisotopic: 307.214743798 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used in the treatment of open-angle glaucoma and ocular hypertension .
How Levobetaxolol works
The exact mechanism by which levobetaxolol lowers intraocular pressure is not known. It it thought that antagonism of β-adrenergic receptors may reduce the production of aqueous humour stimulated via the cyclic adenosine monophosphate-protein kinase A pathway . It is also thought that the vasoconstriction produced by antagonism of β adrenergic receptors reduces blood flow to the eye and therefore the ultrafiltration responsible for aqueous humour production. β1 selective antagonists are less effective than non-selective β adrenergic receptor antagonists because β2 receptors make up the bulk of the population in the eye. They do, however, come with the benefit of reduced respiratory complications.
Elimination Route
Levobetaxolol is applied topically to the eye but some does reach systemic circulaton with a Tmax of 3 h .
Half Life
The mean half life of levobetaxolol is 20 h .
Innovators Monograph
You find simplified version here Levobetaxolol
