Levorphanol

Levorphanol Uses, Dosage, Side Effects, Food Interaction and all others data.

A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.

Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.

Table Of contents

• Levorphanol
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Levorphanol
Availability	Prescription only
Generic	Levorphanol
Levorphanol Other Names	Levorfanol, Levorfanolo, Lévorphanol, Levorphanol, Levorphanolum
Related Drugs	Buprenex, aspirin, acetaminophen, tramadol, naproxen, Tylenol, oxycodone, diazepam, promethazine, Valium
Weight	2mg, 3mg
Type	Oral tablet
Formula	C17H23NO
Weight	Average: 257.3706 Monoisotopic: 257.177964363
Protein binding	40%
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Levorphanol is an opioid analgesic used to treat moderate to severe pain.

For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate.

Levorphanol is also used to associated treatment for these conditions: Severe Pain, Moderate Pain

How Levorphanol works

Like other mu-agonist opioids it is believed to act at receptors in the periventricular and periaqueductal gray matter in both the brain and spinal cord to alter the transmission and perception of pain.

Toxicity

LD₅₀=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.

Food Interaction

• Avoid alcohol.
• Take with or without food. Food does not significantly affect absorption.

Levorphanol Alcohol interaction

[Moderate] GENERALLY AVOID:

Ethanol may potentiate the central nervous system (CNS) depressant effects of opioid analgesics.

Concomitant use may result in additive CNS depression and impairment of judgment, thinking, and psychomotor skills.

In more severe cases, hypotension, respiratory depression, profound sedation, coma, or even death may occur.

Concomitant use of opioid analgesics with ethanol should be avoided.

Levorphanol Drug Interaction

Major: lorazepam, lorazepam, suvorexant, suvorexant, meperidine, meperidine, cyclobenzaprine, cyclobenzaprine, clonazepam, clonazepam, pregabalin, pregabalin, oxycodone, oxycodoneModerate: duloxetine, duloxetineUnknown: acetaminophen, acetaminophen, cholecalciferol, cholecalciferol

Levorphanol Disease Interaction

Major: impaired GI motility, infectious diarrhea, liver disease, prematurity, acute alcohol intoxication, drug dependence, gastrointestinal obstruction, hypotension, intracranial pressure, respiratory depressionModerate: adrenal insufficiency, biliary spasm, hypothyroidism, renal dysfunction, seizure disorders, urinary retention, arrhythmias

Volume of Distribution

• 10 to 13 L/kg

Elimination Route

Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.

Half Life

11-16 hours

Clearance

• 0.78 to 1.1 L/kg/hr

Innovators Monograph

You find simplified version here Levorphanol