Lidanil
Lidanil Uses, Dosage, Side Effects, Food Interaction and all others data.
A phenothiazine antipsychotic with effects similar to chlorpromazine.
Lidanil, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer. Pharmacological studies in laboratory animals have established that mesoridazine has a spectrum of pharmacodynamic actions typical of a major tranquilizer. In common with other tranquilizers it inhibits spontaneous motor activity in mice, prolongs thiopental and hexobarbital sleeping time in mice and produces spindles and block of arousal reaction in the EEG of rabbits. It is effective in blocking spinal reflexes in the cut and antagonizes d-amphetamine excitation and toxicity in grouped mice. It shows a moderate adrenergic blocking activity in vitro and in vivo and antagonizes 5-hydroxytryptamine in vivo. Intravenously administered, it lowers the blood pressure of anesthetized dogs. It has a weak antiacetylcholine effect in vitro.
| Trade Name | Lidanil |
| Availability | Discontinued |
| Generic | Mesoridazine |
| Mesoridazine Other Names | Mesoridazina, Mesoridazine, Mesoridazinum, Thioridazine 2-sulfoxide, Thioridazine thiomethyl sulfoxide |
| Related Drugs | quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone |
| Type | |
| Formula | C21H26N2OS2 |
| Weight | Average: 386.574 Monoisotopic: 386.148654844 |
| Protein binding | 4% |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Lidanil is a phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses.
Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.
How Lidanil works
Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. In addition, the phenothiazines exhibit at least part of their activities through depression of hypothalamic centers. Neurochemically, the phenothiazines are thought to exert their effects by a central adrenergic blocking action.
Toxicity
Oral LD50 is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system.
Food Interaction
- Take with food. Food reduces irritation.
Lidanil Alcohol interaction
[Moderate] GENERALLY AVOID:
Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.
Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.
The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
Patients should be advised to avoid alcohol during phenothiazine therapy.
Lidanil Drug Interaction
Major: clomipramine, clomipramine, bupropion, bupropion, citalopram, citalopramModerate: aripiprazole, aripiprazole, amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, zolpidem, zolpidem, zolpidem, zolpidem, chlordiazepoxide, chlordiazepoxideUnknown: disulfiram, disulfiram
Lidanil Disease Interaction
Major: dementia, acute alcohol intoxication, cardiovascular disease, CNS depression, head injuryModerate: anticholinergic effects, breast cancer, dystonic reactions, hematologic toxicity, liver disease, NMS, parkinsonism, renal dysfunction, respiratory disorders, seizure disorders, tardive dyskinesia
Elimination Route
Well absorbed from the gastrointestinal tract.
Half Life
24 to 48 hours
Innovators Monograph
You find simplified version here Lidanil
