Lidazon Himbo/Citron Lutschten

Uses

Lidazon Himbo/Citron Lutschten is a compound used to reduce plaque and gingivitis, as well as whiten teeth.

Typically employed as the cetylpyridinium chloride salt, this compound is commonly used as an active ingredient in various over-the-counter mouthwashes, toothpastes, lozenges, and mouth sprays where it is generally indicated for antiseptic actions, gingivitis and plaque prevention, as well as action or prevention against some other oropharyngeal bacterial infections .

Lidazon Himbo/Citron Lutschten is also used to associated treatment for these conditions: Gingivitis, Oral Infection, Orofacial Pain, Sore Throat, Stomatitis, Teething pain, Throat irritation, Dry cough, Gum pain, Mouth infection, Oral discomfort and pain, Pain in throat, Throat infections, Throat inflammation, Disinfection, Oral antisepsis, Oral disinfection

How Lidazon Himbo/Citron Lutschten works

When incorporated into mouthwashes, toothpastes, lozenges, or mouth sprays, cetylpyridinium chloride is expected to elicit a mechanism of action that decreases new dental plaque growth, decreases or removes existing dental plaque, diminishes the growth of pathogenic bacteria, and inhibits the production of virulence factors . Lidazon Himbo/Citron Lutschten chloride is a quaternary ammonium compound that demonstrates a broad spectrum anti-bacterial activity . It possesses a cationic surface active agent surfactant which can absorb readily to oral surfaces . The molecules of this agent have both hydrophilic and hydrophobic groups . In action, the positively charged hydrophilic region of cetylpyridinium chloride molecules enables the compound to interact with microbial cell surfaces and even integrate into the bacterial cytoplasmic membrane . Consequently, there is a resultant disruption of bacterial membrane integrity causing a leakage of bacterial cytoplasmic components, interference with cellular metabolism, inhibition of cell growth, and ultimately - cell death . Moreover, cetylpyridinium chloride can also inhibit the synthesis of insoluble glucan by streptococcal glucosyltransferase, adsorb to pellicle-covered enamel, and inhibit co-adhesion of bacteria, and bind streptococcus mutans biofilms . This ability of cetylpyridinium chloride to be able to adsorb to pellicle covered enamel imparts substantivity to the compound molecules - that is retention in the mouth and continued antimicrobial activity for a period of time after rinsing . Taking these mechanisms into consideration, cetylpyridinium chloride may be considered an active ingredient that is effective in the treatment and prevention of bacterial or fungal disorders of the oropharyngeal cavity .

Toxicity

Ingestion of cetylpyridinium chloride in large doses may cause gastric upset and central nervous system depression . However, such overdose symptoms are only observed in doses 70 times greater than the concentrations of cetylpyridinium chloride found in most over-the-counter cetylpyridinium chloride products .

Food Interaction

Volume of Distribution

No readily available data regarding the volume of distribution of cetylpyridinium chloride is available and various products that actually contain cetylpyridinium chloride as an active ingredient suggest that no pharmacokinetic data are available for the agent .

Elimination Route

Most available formulations consisting of cetylpyridinium chloride as an active ingredient are either mouthwashes, tootpastes, lozenges, or mouth sprays. The oral retention of cetylpyridinium chloride given as 1 min mouth rinse of 10 mL of 2.2 MMOL solution was recorded as 65% of the administered dose .

Additionally, it has been recorded that quaternary ammonium compounds like Lidazon Himbo/Citron Lutschten chloride are generally poorly absorbed by the oral route . Furthermore, although systemic absorption from the parenteral route of administration is possible, systemic effects from percutaneous absorption through intact skin is considered rare .

Half Life

No readily available data regarding the half-life of cetylpyridinium chloride is available and various products that actually contain cetylpyridinium chloride as an active ingredient suggest that no pharmacokinetic data are available for the agent .

Clearance

No readily available data regarding the clearance of cetylpyridinium chloride is available and various products that actually contain cetylpyridinium chloride as an active ingredient suggest that no pharmacokinetic data are available for the agent .

Elimination Route

As the quaternary ammonium compound cetylpyridinium chloride is poorly absorbed by oral route, relatively large amounts of the compound are therefore eliminated in faeces .

Innovators Monograph

You find simplified version here Lidazon Himbo/Citron Lutschten