Limy

Limy Uses, Dosage, Side Effects, Food Interaction and all others data.

An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator. [PubChem]

Limy is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Limy is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Limy works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Limy, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.

Trade Name Limy
Availability Prescription only
Generic Phenoxybenzamine
Phenoxybenzamine Other Names Fenossibenzamina, Fenoxibenzamina, Phenoxybenzamine, Phenoxybenzaminum
Related Drugs propranolol, labetalol, Inderal, phentolamine, Normodyne, Trandate
Type
Formula C18H22ClNO
Weight Average: 303.826
Monoisotopic: 303.138992038
Groups Approved
Therapeutic Class
Manufacturer
Available Country Taiwan
Last Updated: September 19, 2023 at 7:00 am
Limy
Limy

Uses

Limy is an alpha adrenergic agonist used to treat pheochromocytoma and episodes of hypertension and sweating.

For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.

Limy is also used to associated treatment for these conditions: Micturition Disorder, Pheochromocytomas, Urinary Retention

How Limy works

Limy produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure.

Toxicity

Symptoms of overdose are largely the result of block of the sympathetic nervous system and of the circulating epinephrine. They may include postural hypotension resulting in dizziness or fainting, tachycardia, particularly postural, vomiting; lethargy, and shock.

Food Interaction

No interactions found.

Elimination Route

Twenty to 30 percent of orally administered phenoxybenzamine appears to be absorbed in the active form.

Half Life

24 hours

Innovators Monograph

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http://classyfire.wishartlab.com/tax_nodes/C0004557
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https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8077
http://www.hmdb.ca/metabolites/HMDB0015061
http://www.genome.jp/dbget-bin/www_bget?cpd:C07435
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4768
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507191
https://www.chemspider.com/Chemical-Structure.4604.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017679
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=8149
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=8077
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL753
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000478
http://www.pharmgkb.org/drug/PA450919
http://www.rxlist.com/cgi/generic3/phenoxybenz.htm
https://www.drugs.com/cdi/phenoxybenzamine.html
https://en.wikipedia.org/wiki/Phenoxybenzamine
*** Taking medicines without doctor's advice can cause long-term problems.
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