Liorin

Liorin Uses, Dosage, Side Effects, Food Interaction and all others data.

A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States.

Liorin belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Liorin hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Liorin has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.

Trade Name Liorin
Availability Discontinued
Generic Promazine
Promazine Other Names Promazin, Promazina, Promazine, Promazinum
Related Drugs quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone, haloperidol, prochlorperazine, Haldol, Compazine
Type
Formula C17H20N2S
Weight Average: 284.419
Monoisotopic: 284.13471934
Protein binding

94%

Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country Croatia (Hrvatska)
Last Updated: September 19, 2023 at 7:00 am
Liorin
Liorin

Uses

Liorin is a phenothiazine used to manage schizophrenia.

Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.

Liorin is also used to associated treatment for these conditions: Psychomotor Agitation, Psychosis, Schizophrenia, Violent Aggressive Behavior

How Liorin works

Liorin is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Liorin's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Liorin does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1)-receptors also occurs with promazine.

Toxicity

Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.

Liorin Alcohol interaction

[Moderate] GENERALLY AVOID:

Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.

Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.

The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.



Patients should be advised to avoid alcohol during phenothiazine therapy.

Elimination Route

Absorption may be erratic and peak plasma concentrations show large interindividual differences.

Innovators Monograph

You find simplified version here Liorin

http://classyfire.wishartlab.com/tax_nodes/C0000000
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http://classyfire.wishartlab.com/tax_nodes/C0001349
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8459
http://www.hmdb.ca/metabolites/HMDB0014564
http://www.genome.jp/dbget-bin/www_bget?drug:D08430
http://www.genome.jp/dbget-bin/www_bget?cpd:C07379
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4926
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504504
https://www.chemspider.com/Chemical-Structure.4757.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67545
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=8742
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=8459
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL564
https://zinc.docking.org/substances/ZINC000000010402
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000430
http://www.pharmgkb.org/drug/PA451126
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/P2Z
https://en.wikipedia.org/wiki/Promazine
*** Taking medicines without doctor's advice can cause long-term problems.
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