Liplac

Liplac Uses, Dosage, Side Effects, Food Interaction and all others data.

A vitamin-like antioxidant.

Liplac (or α-lipoic acid) is able to pass the blood-brain barrier and is putatively used for detoxification of mercury attached to the brain cells. It can mobilise bound mercury into the blood stream as it is a mercaptan (sulfur compound which readily binds to the mercury). In the blood stream, another chelator such as dimercaptosuccinic acid (DMSA) or methylsulfonylmethane (MSM) is used to transfer mercury safely into the urine for excretion. Neither DMSA nor MSM can cross the blood-brain barrier, which is why both lipoic acid and DMSA are used. It is hypothesized that this treatment-along with carnitine, dimethylglycine (DMG), Vitamin B6, folic acid, and magnesium—could be used to treat autism and amalgam poisoning. In this hypothesis, the reason why autism is difficult to treat is that mercury is attached to the brain cells and most medicines and vitamin supplements do not penetrate the blood-brain barrier. However, α-lipoic acid and perhaps vitamin B12 could making it possible for other chelators to remove mercury safely out of the body and could perhaps one day be used as a treatment for autism. Because lipoic acid is related to cellular uptake of glucose and it is both soluble in water and fat, it is being used for treatment in diabetes. It may be helpful for people with Alzheimer's disease or Parkinson's disease.

Trade Name Liplac
Generic Lipoic acid
Lipoic acid Other Names (R)-lipoic acid, Alpha lipoic acid, alpha-Lipoic acid, alpha-Liponsäure, D-thioctic acid, Lipoic acid, R-alpha-lipoic acid, Thioctic acid, Thioctic acid D-form
Weight 600mg
Type Tablet
Formula C8H14O2S2
Weight Average: 206.326
Monoisotopic: 206.043521072
Groups Approved, Investigational, Nutraceutical
Therapeutic Class
Manufacturer Malook Pharmaceuticals Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Liplac
Liplac

Uses

For nutritional supplementation, also for treating dietary shortage or imbalance.

Liplac is also used to associated treatment for these conditions: Diabetic Neuropathies, Type 2 Diabetes Mellitus, Dietary and Nutritional Therapies, Nutritional supplementation

How Liplac works

Lipoic Acid is generally involved in oxidative decarboxylations of keto acids and is presented as a growth factor for some organisms. Liplac exists as two enantiomers, the R-enantiomer and the S-enantiomer. Normally only the R-enantiomer of an amino acid is biologically active, but for lipoic acid the S-enantiomer assists in the reduction of the R-enantiomer when a racemic mixture is given. Some recent studies have suggested that the S-enantiomer in fact has an inhibiting effect on the R-enantiomer, reducing its biological activity substantially and actually adding to oxidative stress rather than reducing it. Furthermore, the S-enantiomer has been found to reduce the expression of GLUT-4s in cells, responsible for glucose uptake, and hence reduce insulin sensitivity.

Food Interaction

No interactions found.

Innovators Monograph

You find simplified version here Liplac

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http://classyfire.wishartlab.com/tax_nodes/C0001116
http://classyfire.wishartlab.com/tax_nodes/C0003086
http://classyfire.wishartlab.com/tax_nodes/C0001423
http://classyfire.wishartlab.com/tax_nodes/C0001989
http://classyfire.wishartlab.com/tax_nodes/C0003372
http://classyfire.wishartlab.com/tax_nodes/C0002800
http://classyfire.wishartlab.com/tax_nodes/C0001137
http://classyfire.wishartlab.com/tax_nodes/C0001205
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:30314
http://www.genome.jp/dbget-bin/www_bget?cpd:C16241
http://www.lipidmaps.org/data/LMSDRecord.php?LMID=LMFA01130001
http://www.hmdb.ca/metabolites/HMDB0014312
http://www.genome.jp/dbget-bin/www_bget?drug:D00086
http://www.genome.jp/dbget-bin/www_bget?cpd:C16241
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6112
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504826
https://www.chemspider.com/Chemical-Structure.5886.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106731
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6417
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=30314
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL134342
https://zinc.docking.org/substances/ZINC000001544807
http://www.pharmgkb.org/drug/PA164776929
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/LPA
https://en.wikipedia.org/wiki/Lipoic_acid
*** Taking medicines without doctor's advice can cause long-term problems.
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