Lodem

Lodem Uses, Dosage, Side Effects, Food Interaction and all others data.

Lodem is a sulfonylurea drug used to treat diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.

Lodem is an anti-diabetic drug in the sulfonylurea class. In patients with diabetes mellitus, there is a deficiency or absence of a hormone manufactured by the pancreas called insulin. Insulin is the main hormone responsible for the control of sugar in the blood. Lodem is an antidiabetic medication which is used in those patients with adult maturity onset or non-insulin dependent diabetes (NIDDM). It works by lowering blood sugar levels by stimulating the production and release of insulin from the pancreas. It also promotes the movement of sugar from the blood into the cells in the body which need it.

Trade Name Lodem
Generic Gliquidone
Gliquidone Other Names Gliquidona, Gliquidone, Gliquidonum
Weight 30mg,
Type Tablet
Formula C27H33N3O6S
Weight Average: 527.632
Monoisotopic: 527.209006493
Groups Approved, Investigational
Therapeutic Class
Manufacturer Dexa Medica
Available Country Indonesia,
Last Updated: September 19, 2023 at 7:00 am
Lodem
Lodem

Uses

Lodem is a sulfonylurea drug used in the management of diabetes mellitus type 2.

Used in the treatment of diabetes mellitus type 2.

Lodem is also used to associated treatment for these conditions: Type 2 Diabetes Mellitus

How Lodem works

The mechanism of action of gliquidone in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Lodem likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin.

Half Life

The mean terminal half-life was approximately 8 hours (range 5.7-9.4 hours)

Innovators Monograph

You find simplified version here Lodem

*** Taking medicines without doctor's advice can cause long-term problems.
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