Lomide (ANTIHISTAMINICES)
Lomide (ANTIHISTAMINICES) Uses, Dosage, Side Effects, Food Interaction and all others data.
Lomide (ANTIHISTAMINICES) is a mast-cell stabilizer for topical administration into the eye. Mast-cell stabilizers, first one approved being cromolyn sodium, are used in treatment of ocular hypersensitivity reactions such as vernal conjunctivitis. These conditions often require treatment with anti-inflammatory medications such as ophthalmic NSAIDs or topical steroids which may cause systemic or toxic effects long-term. Although less effective than topical steroids at decreasing inflammation, mast-cell stabilizers offer another treatment option and exhibit minimal adverse effects. Lomide (ANTIHISTAMINICES) is marketed under the brand name Alomide by Alcon.
Lomide (ANTIHISTAMINICES) is a mast cell stabilizer that inhibits the in vivo Type 1 immediate hypersensitivity reaction. Lomide (ANTIHISTAMINICES) therapy inhibits the increases in cutaneous vascular permeability that are associated with reagin or IgE and antigen-mediated reactions.
| Trade Name | Lomide (ANTIHISTAMINICES) |
| Availability | Prescription only |
| Generic | Lodoxamide |
| Lodoxamide Other Names | Lodoxamida, Lodoxamide |
| Related Drugs | prednisone, diclofenac ophthalmic, ceftriaxone, dexamethasone ophthalmic, triamcinolone, prednisolone ophthalmic, Decadron, Rocephin, cyclosporine ophthalmic, cortisone |
| Type | |
| Formula | C11H6ClN3O6 |
| Weight | Average: 311.63 Monoisotopic: 310.9945126 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | New Zealand |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Lomide (ANTIHISTAMINICES) is an ophthalmic agent used for the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
Indicated in the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
Lomide (ANTIHISTAMINICES) is also used to associated treatment for these conditions: Acute atopic conjunctivitis, Conjunctivitis, Giant Papillary, Conjunctivitis, Vernal, Vernal Keratoconjunctivitis
How Lomide (ANTIHISTAMINICES) works
Although lodoxamide's precise mechanism of action is unknown, it is postulated that it prevents calcium influx into mast cells upon antigen stimulation and therefore stabilizes the membrane. By stabilizing the mast cell membrane from degranulation, lodoxamide consequently inhibits the release of intracellular histamine and other chemoattractant factors that primarily cause ocular symptoms. Lomide (ANTIHISTAMINICES)'s mechanism of action may be similar to cromolyn sodium, as both exhibit cross-tachyphylaxis.
Food Interaction
No interactions found.Elimination Route
In a study of twelve healthy adult volunteers, topical administration of lodoxamide tromethamine ophthalmic solution 0.1%, one drop in each eye four times per day for ten days, did not result in any measurable lodoxamide plasma levels at a detection limit of 2.5 ng/mL.
Half Life
Elimination half-life was 8.5 hours in urine.
Elimination Route
Urinary excretion is the major route of elimination.
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