Lonactene
Lonactene Uses, Dosage, Side Effects, Food Interaction and all others data.
Lonactene is a long-acting synthetic octapeptide analogue of oxytocin. It acts as an agonist at peripheral oxytocin receptors, particularly in the myometrium of uterus.
Lonactene is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is sold under the trade name Duratocin. It is an analogue of oxytocin, and its action is similar to that of oxytocin; it causes contraction of the uterus.
Trade Name | Lonactene |
Generic | Carbetocin |
Carbetocin Other Names | Carbetocin, Carbetocina, Carbetocino, Carbetocinum |
Type | |
Formula | C45H69N11O12S |
Weight | Average: 988.161 Monoisotopic: 987.484787417 |
Groups | Approved, Investigational |
Therapeutic Class | Drugs acting on the Uterus |
Manufacturer | |
Available Country | Mexico |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Lonactene is used for the prevention of uterine atony and postpartum haemorrhage (excessive bleeding) following delivery of the infant by elective caesarean section under epidural or spinal anaesthesia.
Lonactene is also used to associated treatment for these conditions: Postpartum Haemorrhage (PPH), Uterine Atony
How Lonactene works
Lonactene binds to oxytocin receptors present on the smooth musculature of the uterus, resulting in rhythmic contractions of the uterus, increased frequency of existing contractions, and increased uterine tone. The oxytocin receptor content of the uterus is very low in the non-pregnant state, and increases during pregnancy, reaching a peak at the time of delivery.
Dosage
Lonactene dosage
A single intravenous dose of 100 mcg (1 ml) of Carbate (carbetocin injection) is administered by bolus injection, slowly over 1 minute, only when infant delivery has been completed by caesarean section under epidural or spinal anaesthesia.Carbate is to be used as a single dose only.
Side Effects
10-40% of patients experienced nausea, vomiting, abdominal pain, itching skin, increased body temperature, trembling and weakness. Infrequent adverse events (1-5% of patients) included back pain, dizziness, metallic taste, anaemia, sweating, chest pain, dyspnoea, chills, tachycardia and anxiety.
Precaution
In patients who may not have an adequate uterine contraction after a single injection of carbetocin, more aggressive treatment with additional doses of oxytocin or ergometrine is warranted.As carbetocin is closely related in structure to oxytocin, hyponatraemia may occur.Lonactene should be used cautiously in the presence of epilepsy, migraine, asthma or any state in which a rapid addition to extracellular water may produce hazard for an already overburdened system.Patients with eclampsia and pre-eclampsia should be monitored for changes in blood pressure.Lonactene is not recommended for use in elderly patients.
Interaction
No specific drug interactions have been reported with carbetocin.
Food Interaction
No interactions found.Elimination Route
Bioavailability is 80% following intramuscular injection.
Half Life
40 minutes
Pregnancy & Breastfeeding use
Use of carbetocin injection is contraindicated during pregnancy.Use in lactationSmall amounts of carbetocin has been shown to cross over from plasma into the breast milk of nursing women. The small amount of carbetocin ingested by infant would not be expected to present a significant safety concern.
Contraindication
Do not administer before delivery. Vascular disease esp coronary artery disease; hepatic or renal disease.
Special Warning
Pediatrics:No information is available on the relationship of age to the effects of carbetocin in pediatric patients. Safety and efficacy have not been established.
Acute Overdose
Overdosage of carbetocin can be expected to produce enhanced pharmacological effects associated with uterine hyperactivity and pain. Treatment consists of symptomatic and supportive management.
Storage Condition
Store at 2-8°C. Do not freeze. Keep away from light. Once the ampoule has been opened, the product should be used immediately.
Innovators Monograph
You find simplified version here Lonactene
Lonactene contains Carbetocin see full prescribing information from innovator Lonactene Monograph, Lonactene MSDS, Lonactene FDA label