Losagen(PSYCHOANALEPTICS)
Losagen(PSYCHOANALEPTICS) Uses, Dosage, Side Effects, Food Interaction and all others data.
An antipsychotic agent used in schizophrenia. [PubChem]
Losagen(PSYCHOANALEPTICS), a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Losagen(PSYCHOANALEPTICS) is a tranquilizer for which the exact mode of action has not been established, however, it is believed that by antagonising dopamine and serotonin receptors, there is a marked cortical inhibition which can manifest as tranquilization and suppression of aggression.
| Trade Name | Losagen(PSYCHOANALEPTICS) |
| Availability | Prescription only |
| Generic | Loxapine |
| Loxapine Other Names | Loxapina, Loxapine, Loxapinum, Oxilapine |
| Related Drugs | quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone, dexmedetomidine, Loxitane, promazine, Igalmi |
| Type | |
| Formula | C18H18ClN3O |
| Weight | Average: 327.808 Monoisotopic: 327.11383992 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Taiwan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Losagen(PSYCHOANALEPTICS) is a antipsychotic used for the treatment of schizophrenia.
For the management of the manifestations of psychotic disorders such as schizophrenia
Losagen(PSYCHOANALEPTICS) is also used to associated treatment for these conditions: Acute Agitation, Schizophrenia
How Losagen(PSYCHOANALEPTICS) works
Losagen(PSYCHOANALEPTICS) is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Losagen(PSYCHOANALEPTICS) has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior.
Toxicity
LD50=65 mg/kg (Orally in mice)
Food Interaction
- Avoid alcohol.
- Take with food. Food reduces irritation.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Losagen(PSYCHOANALEPTICS) Drug Interaction
Moderate: aripiprazole, aripiprazole, benztropine, benztropine, duloxetine, duloxetine, venlafaxine, venlafaxine, clonazepam, clonazepam, escitalopram, escitalopram, fluoxetine, fluoxetine, quetiapine, quetiapineMinor: lorazepam, lorazepamUnknown: cholecalciferol, cholecalciferol
Losagen(PSYCHOANALEPTICS) Disease Interaction
Major: dementia, CNS depression/coma, related psychosis, previous neuroleptic malignant syndrome (NMS), seizure disorders, acute alcohol intoxication, cardiovascular disease, CNS depression, NMS, tardive dyskinesiaModerate: seizure, cardiovascular disease, glaucoma, hyperprolactinemia/breast cancer, intestinal obstruction, neutropenia, anticholinergic effects, dehydration, hyperprolactinemia, liver disease, parkinsonism
Elimination Route
Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
Half Life
Oral-4 hours
Elimination Route
Metabolites are excreted in the urine in the form of conjugates and in the feces unconjugated.
Innovators Monograph
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