Loxapinum

Loxapinum Uses, Dosage, Side Effects, Food Interaction and all others data.

An antipsychotic agent used in schizophrenia. [PubChem]

Loxapinum, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapinum is a tranquilizer for which the exact mode of action has not been established, however, it is believed that by antagonising dopamine and serotonin receptors, there is a marked cortical inhibition which can manifest as tranquilization and suppression of aggression.

Trade Name Loxapinum
Availability Prescription only
Generic Loxapine
Loxapine Other Names Loxapina, Loxapine, Loxapinum, Oxilapine
Related Drugs quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone, dexmedetomidine, Loxitane, promazine, Igalmi
Type
Formula C18H18ClN3O
Weight Average: 327.808
Monoisotopic: 327.11383992
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Loxapinum
Loxapinum

Uses

Loxapinum is a antipsychotic used for the treatment of schizophrenia.

For the management of the manifestations of psychotic disorders such as schizophrenia

Loxapinum is also used to associated treatment for these conditions: Acute Agitation, Schizophrenia

How Loxapinum works

Loxapinum is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapinum has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior.

Toxicity

LD50=65 mg/kg (Orally in mice)

Food Interaction

  • Avoid alcohol.
  • Take with food. Food reduces irritation.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Elimination Route

Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers

Half Life

Oral-4 hours

Elimination Route

Metabolites are excreted in the urine in the form of conjugates and in the feces unconjugated.

Innovators Monograph

You find simplified version here Loxapinum

*** Taking medicines without doctor's advice can cause long-term problems.
Share