Lufun

Lufun Uses, Dosage, Side Effects, Food Interaction and all others data.

Lufun is a topical antifungal agent. It is a broad-spectrum antifungal agent that belongs to the azole group. It acts against fungus by inhibiting the enzyme lanosterol demethylase and blocks ergosterol synthesis which is an important constituent of fungal cell membrane. Thus it exerts strong fungicidal activity both in-vitro and in-vivo against dermatophytes, Candida albicans, Malassezia spp, Trichophyton and Epidermophyton spp.

Lufun kills the organisms Trichophyton rubrum and Epidermophyton floccosum, most likely by altering their fungal cell membranes.

Trade Name Lufun
Generic Luliconazole
Luliconazole Other Names Luliconazole
Type Cream
Formula C14H9Cl2N3S2
Weight Average: 354.27
Monoisotopic: 352.961495
Protein binding

Plasma protein binding of luliconazole is >99%.

Groups Approved
Therapeutic Class Miscellaneous topical agents
Manufacturer Hitech Formulation
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Lufun
Lufun

Uses

Lufun is used for the topical treatment of interdigital

  • Tinea pedis (athelet's foot),
  • Tinea cruris, and
  • Tinea corporis.

Lufun is also used to associated treatment for these conditions: Tinea Corporis, Tinea Cruris, Tinea Pedis

How Lufun works

The exact mechanism of action for luliconazole's anti-fungal activity is still not known, but luliconazole is thought to inhibit the enzyme lanosterol demethylase. Lanosterol demethylase is needed for the synthesis of ergosterol, which is a major component of the fungus cell membranes.

Dosage

Lufun dosage

Adult:

  • Interdigital tinea pedis: Lufun cream should be applied to the affected area and approximately 1 inch of the immediate surrounding area(s) once daily for two weeks.
  • Tinea cruris and Tinea corporis: Lufun cream should be applied to the affected area and approximately 1 inch of the immediate surrounding area(s) once daily for one week.
Geriatric: Same as adult
Pediatric: Safety and effectiveness have not been established.

Side Effects

Contact dermatitis and cellulitis may occur. Application site reactions were observed in iess than 1% of subjects in clinical trial.

Toxicity

In clinical trials, no serious toxicity was reported, only local irritation (mild contact dermatitis and cellulitis) at the site of application was found.

Precaution

If there is any unusual allergic reaction with the use of Lufun, then treatment should be discontinued and appropriate therapy should be instituted. Lufun is recommended for topical use only. It is not intended for ophthalmic, oral or intravaginal use.

Food Interaction

No interactions found.

Volume of Distribution

The volume of distribution was not quantified.

Elimination Route

Although luliconazole is administered topically, clinical studies have shown that after the first dose in patients with tina pedis, a maximum plasma concentration of 0.40 ± 0.76 ng/mL (mean ± SD) occurred in 16.9 ± 9.39 hours (mean ± SD).

Half Life

The half life of luliconazole has yet to be determined.

Clearance

The clearance of luliconazole has yet to be determined.

Elimination Route

The route of elimination of luliconazole has yet to be determined.

Pregnancy & Breastfeeding use

Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Lufun should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether luliconazole is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Lufun cream is applied to women who are breastfeeding.

Contraindication

None

Storage Condition

Do not store above 30°C. Keep away from light and out of the reach of children.

Innovators Monograph

You find simplified version here Lufun

Lufun contains Luliconazole see full prescribing information from innovator Lufun Monograph, Lufun MSDS, Lufun FDA label

FAQ

What is Lufun used for?

Lufun is indicated for the treatment of athlete's foot, jock itch, and ringworm caused by dermatophytes such as Trichophyton rubrum, Microsporum gypseum and Epidermophyton floccosum. Lufun cream is used to treat: Ringworm of the body ; Ringworm of the foot between the toes; and Ringworm of the groin.

How safe is Lufun?

Lufun when applied once daily to all 10 fungus-infected toenails for 29 days, is generally safe and well tolerated and results in significant accumulation of drug in the nail.

How does Lufun work?

Lufun works by slowing the growth of fungi that cause infection.

What are the common side effects of Lufun?

Common side effects may include mild skin irritation where the medicine was applied.

Is Lufun safe during pregnancy?

There are no adequate and well-controlled studies of Lufun in pregnant women. Lufun should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn baby.

Is Lufun safe during breastfeeding?

Lufun has not been studied during breastfeeding; low risk to the nursing infant expected as this drug is poorly absorbed after topical use and is highly plasma protein bound. Application to the nipple area should be avoided.

Can I drink alcohol with Lufun?

You can drink alcohol while taking Lufun.

Can I drive after taking Lufun ?

Lufun may occasionally cause dizziness which may affect your ability to drive or operate machinery.

How long does Lufun take to work?

Lufun is usually applied once a day for 1 week. To treat athlete's foot, Lufun is usually applied once a day for 2 weeks.

Can I take Lufun for a long time?

You usually take Lufun for a short time to clear an infection. If you have a serious infection, you may need to take Lufun long term. It is safe to take for a long time if your doctor has advised you to.

Who should not take Lufun?

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What happens if I overdose of Lufun?

Seek emergency medical attention. Overdose symptoms may include confusion or unusual thoughts or behavior.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happen If I stop taking Lufun?

If you stop taking the drug suddenly or don't take it at all your infection may not get better or may get worse.

Can I take Lufun every other day?

You'll usually take Lufun once a day.

Can Lufun damage the liver?

The severity of liver injury from Lufun ranges from mild and transient enzyme elevations to clinically apparent hepatitis to acute liver failure and death.

Is Lufun bad for kidneys?

Increased side effects can include kidney damage. Your doctor will check your blood for signs of kidney damage while you're taking Lufun. If you show signs of kidney damage, your doctor may lower your doses of these drugs or stop them completely until your treatment with Lufun is done.

Can Lufun affect my fertility?

An experimental animal study did not find Lufun to affect fertility.

*** Taking medicines without doctor's advice can cause long-term problems.
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