Lumasiran

Lumasiran Uses, Dosage, Side Effects, Food Interaction and all others data.

Lumasiran is a small interfering RNA used in the treatment of primary hyperoxaluria type 1 (PH1). This condition, caused by a deficiency in the enzyme alanine-glyoxylate aminotransferase, leads to an accumulation of oxalate, causing calcium crystal formation. These patients experience frequent kidney stones, nephrocalcinosis, and renal failure.

Oxlumo, producted by Alnylam Pharmaceuticals, represents the first approved treatment for PH1. Prior to this approval, therapy consisted of symptomatic treatment such as hyperhydration, inhibitors of crystallization, pyridoxine, and renal transplant.

Lumasiran was granted FDA approval on 23 November 2020.

Trade Name Lumasiran
Availability Prescription only
Generic Lumasiran
Lumasiran Other Names Lumasiran
Related Drugs Oxlumo
Weight 94.5mg/0.5ml
Type Subcutaneous solution
Protein binding

Lumasiran is 77% to 85% bound to protein in plasma.

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Lumasiran
Lumasiran

Uses

Lumasiran is lumasiran is an interfering RNA that silences hydroxyacid oxidase 1 for the treatment of primary hypoxaluria type 1.

Lumasiran is indicated for the treatment of primary hyperoxaluria type 1.

Lumasiran is also used to associated treatment for these conditions: Primary Hyperoxaluria Type I

How Lumasiran works

Patients with primary hyperoxaluria type 1 produce an excess of oxalate due to a deficiency in the enzyme alanine-glyoxylate aminotransferase.

Lumasiran is a small interfering RNA that silences the gene hydroxyacid oxidase 1 (HOA1). Lumasiran targets HOA1 mRNA, preventing translation to the enzyme glycolate oxidase (GO). Reduced levels of GO, reduce levels of glyoxylate, leaving less reactants available for metabolism to oxalate. In the ILLUMINATE trials, lumasiran reduced oxalate levels in 84% of adults and children over 6 years to at or below 1.5 times the upper limits of normal.

Toxicity

Data regarding overdoses of lumasiran are not readily available. In the event of an overdose, patients should be monitored for signs of adverse reactions and be treated symptomatically.

Food Interaction

No interactions found.

Lumasiran Disease Interaction

Moderate: liver dysfunction, renal dysfunction

Volume of Distribution

The apparent central volume of distribution based on population estimate is 4.9 L.

Elimination Route

In patients ≥20 kg; a 3 mg/kg subcutaneous dose of lumasiran reacheas a Cmax of 529 ng/mL, with a Tmax of 4.0 hours, and an AUC of 7400 ng*h/mL. In patients max of 912 ng/mL and an AUC of 7960 ng*h/mL.

Half Life

The mean terminal half life of lumasiran is 5.2 hours.

Clearance

The apparent plasma clearance of lumasiran based on population estimate is 26.5 L/h for an average 70 kg adult. The mean renal clearance is 2.0-3.4 L/h.

Elimination Route

7-26% of a dose of lumasiran is recovered in the urine as the unmetabolized parent compound.

A radiolabelled dose administered to rats was 19.5% recovered in urine and 33.9% recovered in feces.

Innovators Monograph

You find simplified version here Lumasiran

*** Taking medicines without doctor's advice can cause long-term problems.
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