Lyzapam
Lyzapam Uses, Dosage, Side Effects, Food Interaction and all others data.
Lormatazepam is an orally available benzodiazepine used in the UK for the treatment of short-term insomnia . It is marketed by Auden Mckenzie (Pharma Division) in 0.5 and 1 mg tablet formulations.
Lyzapam is a benzodiazepine which reduces central nervous system (CNS) activity . It produces anxiolytic, muscle relaxant, sedative and hypnotic effects. Because it is a short-acting benzodiapine, it does not produce significant sedation after waking.
Trade Name | Lyzapam |
Generic | Lormetazepam |
Lormetazepam Other Names | (RS)-Lormetazepam, Lormetazepam, Methyllorazepam, N-Methyllorazepam |
Weight | 1000mcg |
Type | Tablet |
Formula | C16H12Cl2N2O2 |
Weight | Average: 335.185 Monoisotopic: 334.027583052 |
Groups | Approved |
Therapeutic Class | |
Manufacturer | Atco Laboratories Limited |
Available Country | Pakistan |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Lyzapam is a benzodiazepine indicated in the treatment of anxiety and the induction of anesthesia.
For the treatment of short-term insomnia
Lyzapam is also used to associated treatment for these conditions: Severe Insomnia, Sleep Disorder, Acute Anxiety
How Lyzapam works
Lyzapam, as a benzodiazepine, binds to the regulatory site between the α and γ subunits of γ-aminobutryic acid (GABA) A receptors with γ2 and α1, α2, α3, or α5 subunits . This facilitates the opening of the chloride channel allowing chloride ions to flow into the neuron resulting in hyperpolarization. Hyperpolarized neurons require greater simulation to reach their action potential threshold. The general inhibitory effect on neuronal depolarization produces the effects of lormetazepam.
Toxicity
The primary manifestation of overdosage ranges from drowsiness to coma and symptoms may include ataxia, hypotension, hypotonia, respiratory depression which may lead to death .
Experimental LD50 values are as follows : Mouse - 780 mg/kg (intraperitoneal), 1790 mg/kg (oral), 10000 mg/kg (subcutaneous). Rat - 6250 mg/kg (intraperitoneal), 10000 mg/kg (oral), 10000 mg/kg (intraperitoneal).
Half Life
The terminal phase half life is 11 h .
Innovators Monograph
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