Mac Ppi
Mac Ppi Uses, Dosage, Side Effects, Food Interaction and all others data.
Mac Ppi is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.
Mac Ppi is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Trade Name | Mac Ppi |
Generic | Domperidone |
Domperidone Other Names | Domperidona, Domperidone, Domperidonum |
Type | Dsr Capsule |
Formula | C22H24ClN5O2 |
Weight | Average: 425.911 Monoisotopic: 425.161852744 |
Protein binding | 91%-93% |
Groups | Approved, Investigational, Vet approved |
Therapeutic Class | Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs |
Manufacturer | Corona Remedies Pvt Ltd |
Available Country | India |
Last Updated: | September 19, 2023 at 7:00 am |
![Mac Ppi Mac Ppi](https://www.medicinesfaq.com/media/png/mac-ppi.png)
Uses
Stimulation of gut motility in-
- Non-ulcer dyspepsia
- Oesophageal reflux, reflux oesophagitis and gastritis
- Diabetic gastroparesis
- Functional dyspepsia
- Speeding barium transit in follow through radiological studies
Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.
In the prophylactic treatment of migraine.
Mac Ppi is also used to associated treatment for these conditions: Diabetic Gastroparesis, Dyspepsia, Erosive Esophagitis, Gastrointestinal Symptoms, Non-erosive Reflux Esophagitis Disease (NERD), Upper gastrointestinal motility disorders
How Mac Ppi works
Mac Ppi acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Mac Ppi facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting
Dosage
Mac Ppi dosage
Adults: 10 - 20 mg every 4 - 8 hours daily
Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.
Mac Ppi tablet and suspension should be taken 15 - 30 minutes before a meal. For acute nausea and vomiting, maximum period of treatment is 12 weeks.
Side Effects
Mac Ppi may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.
Toxicity
Side effects include galactorrhea, gynecomastia, or menstrual irregularities.
Precaution
Mac Ppi should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.
Interaction
Mac Ppi may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Mac Ppi on gastrointestinal function.
Food Interaction
- Take before a meal. Take 15-30 minutes before meals.
Half Life
7 hours
Pregnancy & Breastfeeding use
Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.
Use in lactation: Mac Ppi may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.
Contraindication
Mac Ppi is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.
Acute Overdose
Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.
Storage Condition
Store in a cool dry place protected from light. Keep out of reach of children.
Innovators Monograph
You find simplified version here Mac Ppi
Mac Ppi contains Domperidone see full prescribing information from innovator Mac Ppi Monograph, Mac Ppi MSDS, Mac Ppi FDA label
FAQ
What is Mac Ppi used for?
Mac Ppi help to stop feeling or being sick like as nausea or vomiting.It can also be used to treat stomach pain if you're having end of life care. Mac Ppi is sometimes used to increase milk supply.
Is Mac Ppi safe to take?
For most people, taking Mac Ppi is safe.If you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate.
What are the side effects of Mac Ppi?
Common side effects of Mac Ppi are include:
- swelling of the ankles/feet.
- unusual tiredness.
- mental/mood changes (e.g., nervousness, irritability)
- hot flashes.
- breast swelling/pain.
- unusual leakage of milk from the breast.
- changes in menstrual periods.
- decreased sexual ability.
Is Mac Ppisafe during pregnancy?
Mac Ppi is not usually recommended in pregnancy.
Why Mac Ppi is not safe in pregnancy?
Mac Ppi is contraindicated for use in pregnant women and in women suspected of being pregnant, due to teratogenicity observed in reproductive toxicity studies.
Is Mac Ppi safe during breastfeeding?
A very small amount of the Mac Ppi you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking Mac Ppi.
Can I drink alcohol with Mac Ppi?
It is best to avoid alcohol when taking Mac Ppi. Drinking alcohol can make side effects worse, such as sleepiness or an irregular heartbeat.
How long does Mac Ppi take to work?
Mac Ppi often takes at least three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer.
Can I take Mac Ppi before bed?
Mac Ppi is best taken 15 to 30 minutes before meals and id necessary at bedtime.
Is Mac Ppi good for acid reflux?
It decreases postprandial reflux time and is therefore used to treat regurgitation and vomiting.
Can I take Mac Ppi after eating?
Mac Ppi is best taken about 15 to 30 minutes before meals, with a glass of water. If you take Mac Ppi after a meal, it will still work, but it may take longer to have an effect.
Is Mac Ppi good for gastritis?
Mac Ppi has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment.Mac Ppi is a kind of drug to strengthen gastric motility.
What does Mac Ppi do to your body?
Mac Ppi is a medicine that increases the movements or contractions of the stomach and bowel. Mac Ppi is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.
Is Mac Ppi safe for kidneys?
Mac Ppi are not significantly renally cleared and can be used in CKD.
Does Mac Ppi help anxiety?
Mac Ppi is used to treat severe anxiety like as emotional state where you may sweat, tremble, feel anxious and have a fast heartbeat or agitation.
Does Mac Ppi raise blood pressure?
Mac Ppi increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.
Is Mac Ppi a narcotic?
Mac Ppi is not a controlled substance e.g. sleeping pills, valium, narcotics.
Does Mac Ppi cause depression?
Mac Ppi can cause central nervous system side effects such as fatigue, irritability, or depression.
Can I take Mac Ppi for a long time?
You should usually take Mac Ppi for up to a week.Because Mac Ppi can cause an irregular heartbeat if you take it for longer or at a high dose.
What happens when I stop taking Mac Ppi?
Most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother's milk supply to adjust without frustrating the baby or causing her discomfort. It is very important to stop the Mac Ppi slowly.