Mactase
Mactase Uses, Dosage, Side Effects, Food Interaction and all others data.
Lactase is an enzyme that helps to prevent symptoms of lactose intolerance by breaking down milk sugar (lactose) to produce glucose and galactose via hydrolysis and making dairy foods easier to digest.
The use of a single oral administration of tilactase has been shown to be highly effective in decreasing the symptoms and hydrogen excretion of hypolactasia in tests of lactose H(2)-breath. The analysis has shown a decrease of approximately 80% in both malabsorbers and intolerants.The administration of tilacatase also decreases the presence of bloating and flatus.
| Trade Name | Mactase |
| Generic | Tilactase |
| Tilactase Other Names | beta-D-Galactosidase, beta-Galactosidase, Lactase, Tilactasa, Tilactase, Tilactasum |
| Type | Drops |
| Weight | 102000.0 Da |
| Protein binding | Tilactase is not absorbed and thus the plasma protein binding is not possible. |
| Groups | Approved, Experimental |
| Therapeutic Class | Anti-diarrhoeal Enzyme |
| Manufacturer | Macleods Pharmaceuticals |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Lactase is used for preventing symptoms of lactose intolerance such as bloating, flatulence, diarrhea etc.
Mactase is also used to associated treatment for these conditions: Lactose Intolerance
How Mactase works
Lactose is the primary disaccharide found in dairy products. Mactase is a type of lactase which is the enzyme that is in charge of the breakdown of lactose to glucose and galactose which can be used by the body. Basically, tilactase acts by replacing the missing lactase in the body and allows avoidance of the reach of lactose to the small intestine and the normal bacteria and thus, preventing the symptoms of the lactose intolerance. Once tilactase has metabolized the lactose, the metabolism products are reabsorbed by the normal process of digestion.
Dosage
Mactase dosage
Adult: 1 tablet (300 mg) with dairy food. If needed dose can be adjusted up to 2 tablets (600 mg) at a time.
Children: Effective & safe in children above 4 years of age.
Side Effects
There are no major side effects reported. The very few side effects may include rash, difficulty in breathing, tightness in chest etc.
Toxicity
Mactase is known to present a low acute oral toxicity in preclinical trials. The lowest toxic dose for subcutaneous exposure is of 26 g/kg administered over 30 days. There have not been performed enough studies regarding the use of pregnancy or related to the fetal development. There are no reports of overdose with tilactase.
Interaction
No information for lactase interactions has been found yet.
Food Interaction
- Take before a meal. Take tilactase before eating food containing lactose.
Volume of Distribution
Mactase is not absorbed and thus the volume of distribution is not relevant.
Elimination Route
Mactase is not absorbed in the GI tract and thus the pharmacokinetic parameters related to absorption are not relevant.
Half Life
Mactase half-life at 35ºC is registered to be 123.77 min. This half-life can be affected by temperature in an inversely proportional manner.
Clearance
Mactase is not absorbed and thus the clearance rate is not relevant.
Elimination Route
Mactase is completely eliminated in the feces either unchanged or as metabolites.
Pregnancy & Breastfeeding use
Use in Pregnancy: It is unknown if lactase may cause harm to the fetus. Therefore, lactase should be given during pregnancy only when clearly needed.
Use in lactating mother: It is unknown if lactase is excreted in breast milk. Thus, lactase should be given during lactation only when clearly needed.
Contraindication
This drug is contraindicated in patients with known hypersensitivity to lactase or any other components of the product.
Innovators Monograph
You find simplified version here Mactase
