Mag-sr
Mag-sr Uses, Dosage, Side Effects, Food Interaction and all others data.
Mag-sr salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water.
Magnesium is important as a cofactor in many enzymatic reactions in the body involving protein synthesis and carbohydrate metabolism (at least 300 enzymatic reactions require magnesium). Actions on lipoprotein lipase have been found to be important in reducing serum cholesterol and on sodium/potassium ATPase in promoting polarization (eg, neuromuscular functioning).
| Trade Name | Mag-sr |
| Generic | Magnesium chloride |
| Weight | 200mg/ml |
| Type | Injectable solution, injection |
| Formula | Cl2Mg |
| Weight | Average: 95.211 Monoisotopic: 93.922747312 |
| Protein binding | 30%, to albumin |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Mag-sr is an ionic compound and source of magnesium used for electrolyte replenishment and conditions associated with magnesium deficiencies.
Mag-sr is used in several medical and topical (skin related) applications. Mag-sr usp, anhydrous uses as electrolyte replenisher, pharmaceutic necessity for hemodialysis and peritoneal dialysis fluids.
Mag-sr is also used to associated treatment for these conditions: Electrolyte imbalance, Magnesium Deficiency, Mild Metabolic acidosis, Automated peritoneal dialysis, Continuous Renal Replacement Therapy, Continuous ambulatory peritoneal dialysis therapy, Fluid replacement therapy, Hemodialysis Treatment, Irrigation therapy, Organ Preservation, Parenteral rehydration therapy, Peritoneal dialysis therapy, Total parenteral nutrition therapy, Urine alkalinization therapy, Fluid and electrolyte maintenance therapy
How Mag-sr works
Mechanism of action of magnesium chloride studied in 10 adult volunteers. Results suggested magnesium ion in duodenum is relatively weak stimulus to pancreas and gall bladder. It is weak stimulant to cholecystokinin release and inhibits net jejunal water absorption. The oral administration of a single 800 mg dose of magnesium chloride in healthy volunteers resulted in a diminished rate of intraluminal lipid and protein digestion. The most pronounced effect of magnesium chloride, however, was a decreased gastric emptying rate of both test meals. After correction for gastric emptying, no differences were noted in intraluminal lipid or protein digestion. Therefore, the lower lipid levels noted after magnesium supplementation are unlikely to be the result of altered lipid assimilation. Mag-sr slows gastric emptying but does not influence lipid digestion.
Toxicity
Mouse LD50 775mg/kg (intraperitoneal) Mouse LD50 : 7600mg/kg (oral) Rat LD 50 : 8100mg/kg (oral) Rat LD50 176mg/kg (intravenous) Severe toxicity occurs most often after intravenous infusions. It can also occur after chronic excessive oral doses, often in patients with renal insufficiency. Early manifestations are lethargy, hyporeflexia, followed by weakness, paralysis, hypotension, ECG changes (prolonged PR and QRS intervals), CNS depression, seizures, and respiratory depression. In overdose, magnesium impairs neuromuscular transmission, manifested as weakness and hyporeflexia.
Food Interaction
- Take with or without food. Taking magnesium supplements with food may reduce the risk of diarrhea.
Volume of Distribution
Bone (50% to 60%); extracellular fluid (1% to 2%)
Elimination Route
Oral: Inversely proportional to amount ingested; 40% to 60% under controlled dietary conditions; 15% to 36% at higher doses
Half Life
Elimination half-life has been reported to be 27.7 hours following an overdose of 400 mEq magnesium in an adult.
Clearance
Maximum magnesium clearance is directly proportional to creatinine clearance.
Elimination Route
Magnesium is excreted in urine. Unabsorbed magnesium is excreted in feces
Innovators Monograph
You find simplified version here Mag-sr
