Magnesium diacetate tetrahydrate
Magnesium diacetate tetrahydrate Uses, Dosage, Side Effects, Food Interaction and all others data.
Magnesium diacetate tetrahydrate is a hydrated form of anhydrous magnesium acetate salt with the chemical formula of Mg(CH3COO)2 • 4H2O. As a salt form of magnesium, magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble compound. Magnesium is an essential element and second most abundant cation in the body that plays a key role in maintaining normal cellular function such as production of ATP and efficient enzyme activity. Magnesium diacetate tetrahydrate can be used as an electrolyte supplementation or a reagent in molecular biology experiments.
Magnesium is an essential cofactor for many enzymatic reactions such as protein synthesis and ATP production. It also participates in adenylyl cyclase pathway and tyrosine kinase signalling pathways. Magnesium may also play a role in regulating glucose metabolism. It serves as an essential cation for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions.
| Trade Name | Magnesium diacetate tetrahydrate |
| Generic | Magnesium acetate tetrahydrate |
| Magnesium acetate tetrahydrate Other Names | Magnesium diacetate tetrahydrate |
| Type | |
| Formula | C4H14MgO8 |
| Weight | Average: 214.453 Monoisotopic: 214.05390911 |
| Protein binding | Protein binding of magnesium ions is about 30% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Magnesium diacetate tetrahydrate is an ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.
Used as magnesium salf-containing laxatives to prevent constipation. It can bring synergistic effect to restore normal bowel function when using in combination with aluminum salts that induce bowel retention . Magnesium diacetate tetrahydrate is used as a source of water and electrolytes when combined with dextrose and other salts to form intravenous infusions. This injection can be used for patients with carbohydrate or magnesium deficiency, insulin hypoglycemia, constipation or hypertension during pregnancy.
Magnesium diacetate tetrahydrate is also used to associated treatment for these conditions: Fluid replacement therapy, Total parenteral nutrition therapy, Urine alkalinization therapy
How Magnesium diacetate tetrahydrate works
Magnesium ions electrostatically stabilize the adenylyl cyclase complex and enhance its catalytic actions and production of cAMP. They also regulate the level of phosphorylation in various pathways by formation of transition state of phosphoryl transfer reaction by protein kinases and stabilize ATP binding to protein kinases via electrostatic interactions . Many metabolic enzymes involved in glycolysis and Krebs cycle are magnesium-dependent. Magnesium-containing laxatives cause diarrhea through water retention and increased fecal mass that stimulates peristalsis. When used as an electrolyte supplementation, magnesium acetate tetrahydrate induces diuresis and metabolic alkalinizing effect. Magnesium ions enhance reactivity of arteries to vasoconstrictors, promotes vasoconstriction, and increases peripheral resistance, leading to increased blood pressure through potential competition with calcium ions in the vascular system. Magnesium ions also regulate other ions entering and exiting the cell membrane by acting as a ligand in N-methyl-D-aspartate receptor.
Toxicity
Predicted oral LD50 value is >2000mg/kg. In case of mild to moderate toxicity, it may cause irritation in case of skin or eye contact,and nausea or vomiting from ingestion and inhalation. In overdose, magnesium impairs neuromuscular transmission, manifested as weakness and hyporeflexia. Early manifestations of severe toxicity are lethargy, hyporeflexia, followed by weakness, paralysis, hypotension, ECG changes (prolonged PR and QRS intervals), CNS depression, seizures, and respiratory depression.
Food Interaction
No interactions found.Volume of Distribution
Magnesium ions display approximate volume of distribution of 0.2 to 0.4 L/kg
Elimination Route
Intestinal absorption is achieved mainly through passive diffusion.
Half Life
Elimination half-life has been reported to be 27.7 hours following an overdose of 400mEq magnesium in an adult.
Elimination Route
Mainly renal exctretion, where up to 97% of magnesium may be excreted renally during hypermagnesemia.
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