Magnesium silicate
Magnesium silicate Uses, Dosage, Side Effects, Food Interaction and all others data.
Magnesium silicate is a compound of magnesium oxide and silicon. It is the magnesium salt of silicic acid containing an unspecified amount of water. The molecular formula can be expressed more clearly as MgSiO3.xH2O. It is known as talc and it presents many uses in the cosmetic industry, food industry and pharmaceutical industry. Under the FDA, magnesium silicate is determined as a member of the substances generally recognized as safe (GRAS) to be used as an anticaking agent.
| Trade Name | Magnesium silicate |
| Generic | Magnesium silicate |
| Type | |
| Formula | MgO3Si |
| Weight | Average: 100.387 Monoisotopic: 99.9467121 |
| Protein binding | The very low absorption of magnesium silicate makes its pharmacokinetic properties not relevant. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Magnesium silicate is used to absorb moisture, prevent caking, and to improve the feel of a product. In the pharmaceutical companies, it is used as a dietary supplement, as part of the formulation ingredients in drug production, in antacid and antiulcer preparations, as a component of antiepileptic drugs, in antifungal topical agents and in the treatment of acne and as a facial moisturizer.
When complexed with arginine, magnesium silicate can be used as an antiatherosclerotic agent and to promote bone and cartilage formation in mammals.
How Magnesium silicate works
As a supplement, magnesium silicate acts by replacing the factor that is missing. In the case of antacids, it is a non-absorbable antacid whose main activity is related to the absorption of hydrochloric acid. More specifically, magnesium silicate acts as a neutralizing and astringent agent.
Toxicity
The administration of more than 50 meq of magnesium daily can produce the development of hypermagnesemia. This can provoke the formation of bladder and renal calculi. There is no known toxicity and the LD50 in animals are higher than 500 mg/kg in humans. It is determined that magnesium silicate is not carcinogenic.
Volume of Distribution
The very low absorption of magnesium silicate makes its pharmacokinetic properties not relevant.
Elimination Route
Orally administered magnesium silicate is rapidly neutralized in the stomach and it forms magnesium chloride and silicon dioxide. From the modified portion, some of the formed magnesium is absorbed. The very low absorption of magnesium silicate makes its pharmacokinetic properties not relevant.
Half Life
The very low absorption of magnesium silicate makes its pharmacokinetic properties not relevant.
Clearance
The very low absorption of magnesium silicate makes its pharmacokinetic properties not relevant.
Elimination Route
The very low absorption of magnesium silicate makes its pharmacokinetic properties not relevant.
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