Magphate
Magphate Uses, Dosage, Side Effects, Food Interaction and all others data.
Magphate is classified as an alkaline earth metal and has 2 hydration shells. The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate.
Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy greens. Magphate is an important enzyme cofactor and is essential to several metabolic processes. Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein synthesis among several other functions.
Despite the importance of magnesium and its availability via several food sources, an estimated 56 to 68% of adults who live in developed, western countries do not meet the recommended daily intake (RDI) of magnesium. Several factors and common behaviours reduce the availability of magnesium in the diet such as food processing and cooking vegetables (which are normally a rich source of magnesium).
| Trade Name | Magphate |
| Availability | Rx and/or OTC |
| Generic | Magnesium |
| Magnesium Other Names | Magnesio, Magnésium, Magnesium metallicum, Magnesium powder |
| Related Drugs | clonazepam, lamotrigine, diazepam, topiramate, Lamictal, Klonopin, sotalol, magnesium oxide, acebutolol, Epsom Salt |
| Type | Injection |
| Formula | H2Mg |
| Weight | Average: 26.321 Monoisotopic: 26.00069176 |
| Protein binding | 20% of the magnesium found in human serum is protein bound. Approximately 60-70% of this fraction is bound to albumin while the remainder is bound to globulin proteins. Magnesium has the ability to bind to 3751 human proteins. |
| Groups | Approved, Experimental, Investigational |
| Therapeutic Class | |
| Manufacturer | Lincoln Pharmaceuticals Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Magphate is a medication used for many purposes including constipation, indigestion, magnesium deficiency, and pre-eclampsia.
Healthy levels of magnesium can be achieved through a well balanced diet, but if food sources are insufficient, magnesium supplements can be used to prevent and treat magnesium deficiencies.
In medicine, various magnesium salts may be used in laxative and antacid products. For example, magnesium citrate is available over-the-counter and may be used to manage occasional constipation. Magphate sulfate may be used on its own or with total parenteral nutrition to treat hypomagnesemia. Magphate sulfate is also indicated to prevent seizures in pregnant women with pre-eclampsia, and to manage seizures associated with eclampsia.
Magphate is also used to associated treatment for these conditions: Calcium Deficiency, Magnesium Deficiency, Zinc Deficiency
How Magphate works
Magphate is a cofactor for at least 300 enzymes and is important for several functions in the body with some key processes identified below. Enzymes that rely on magnesium to operate help produce energy through oxidative phosphorylation, glycolysis and ATP metabolism. They are also involved in nerve function, muscle contraction, blood glucose control, hormone receptor binding, protein synthesis, cardiac excitability, blood pressure control, gating of calcium channels and transmembrane ion flux.
The mitochondrial intracellular space is rich in magnesium, since it is required to produce the active form of ATP (adenosine triphosphate) from ADP (adenosine diphosphate) and inorganic phosphate, and behaves as a counter ion for the energy rich molecule. Additionally, magnesium is essential for ATP metabolism.
Toxicity
The recommended dietary allowance of magnesium ranges from 30 mg for infants to 420 mg for males between the age of 31 and 50. According to the institute of Medicine (IOM), the majority of adults can tolerate 350 mg of magnesium per day without experiencing adverse effects. Symptoms of magnesium toxicity include diarrhea and other gastrointestinal effects, thirst, muscle weakness, drowsiness, severe back and pelvic pain, hypotension, dizziness, confusion, difficulty breathing, lethargy, and deterioration of kidney function. Other more severe symptoms associated with magnesium overdose include loss of consciousness, respiratory arrest, cardiac arrhythmias and cardiac arrest.
Regular use of laxatives containing magnesium may lead to severe and even fatal hypermagnesemia.
Discontinuation of magnesium products including supplements, laxatives, and antacids is usually sufficient to manage mild cases of magnesium overdose; however, patients should also be screened for renal impairment.
In severe cases of magnesium overdose, patients may require supportive care and interventions including intravenous fluids and furosemide, IV calcium chloride or calcium gluconate, renal dialysis and artificial respiratory support.
Food Interaction
- Take with or without food. Taking magnesium supplements with food may reduce the risk of diarrhea.
Magphate Disease Interaction
Major: depression, inflammatory bowel disease, intestinal obstruction disorders, cardiac disease, pregnancy, renal dysfunction, myasthenia gravisModerate: arrhythmias
Volume of Distribution
According to a pharmacokinetic review, the volume of distribution of magnesium sulphate when used to manage patients with pre-eclampsia and eclampsia ranged from 13.65 to 49.00 L.
Elimination Route
Approximately 24-76% of ingested magnesium is absorbed in the gastrointestinal tract, primarily via passive paracellular absorption in the small intestine.
Half Life
Magphates biologic half-life is reported to be approximately 1000 hours or 42 days.
Elimination Route
The majority of magnesium is excreted renally.
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