Makmin
Makmin Uses, Dosage, Side Effects, Food Interaction and all others data.
Makmin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
| Trade Name | Makmin |
| Generic | Mecobalamin |
| Mecobalamin Other Names | Co-methylcobalamin, MeCbl, Mecobalamin, Mecobalamina, Mecobalaminum, Methyl vitamin B12, Methyl(III)cobalamin, Methylcobalamin |
| Weight | 500mcg |
| Type | Tablet |
| Formula | C63H91CoN13O14P |
| Weight | Average: 1344.3823 Monoisotopic: 1343.587806391 |
| Groups | Approved, Investigational |
| Therapeutic Class | Drugs for Megaloblastic Anemia |
| Manufacturer | Makson Pharmaceuticals |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Makmin is used for-
- Peripheral Neuropathies
- Diabetic Neuropathy
- Verteberal Syndrome
- Nerve Compression Syndrome
- Multiple sclerosis
- Amyotrophic lateral sclerosis
- Parkinson’s disease
- Alzheimer’s disease
- Diabetic retinopathy
- Entrapment neuropathy
- Drug induced neuropathy
- Megaloblastic anemia due to Vitamin B12 deficiency
Makmin is also used to associated treatment for these conditions: Vitamin B12 Deficiency, Nutritional supplementation
Dosage
Makmin dosage
Tablet: The usual adult dosage is one 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.
Injection:
- Peripheral neuropathies: The usual adult dosage is one ampoule equivalent to 500 mcg of Makmin, administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
- Megaloblastic anemia: The usual adult dosage is one ampoule equivalent to 500 mcg of Makmin, administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Makmin every one to three months as maintenance therapy
Side Effects
Generally Makmin is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Makmin.
Precaution
The medicine should not be used for months if there is no response at all after its use for a certain period of time.
Interaction
Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
Not recommended during pregnancy & lactation.
Contraindication
Hypersensitivity to any component of this product.
Special Warning
Use in children: Not recommended.
Storage Condition
Oral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Innovators Monograph
You find simplified version here Makmin
FAQ
What is Makmin used for?
Makmin is used to treat vitamin B12 deficiency.
How safe is Makmin?
Makmin is considered likely safe when used appropriately.
How does Makmin work?
Makmin works by functioning in the production of a compound called myelin, which covers and protect nerve fibers.
What are the common side effects of Makmin?
Common side effects of Makmin are include:
- Nausea.
- Vomiting.
- Diarrhea.
- Loss of appetite.
- Headache.
Is Makmin safe during pregnancy?
Pregnancy There are no data available for Makmin to be used in pregnant women.
Is Makmin safe during breastfeeding?
There are no data available for Makmin to be used in lactating women.
Can I drink alcohol with Makmin?
No interactions were found between Alcohol and Makmin. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Can I take Makmin daily?
The recommended dose is 500 mcg three times daily or 1500 mcg daily. Most generic vitamins contain cyanocobalamin, which may not be as effective or as beneficial.
How much Makmin should I take?
The general recommendation for adults is 2.4 mcg. Older adults, as well as pregnant and breastfeeding women, require higher doses.
Should I take Makmin on an empty stomach?
It is a well-known medical fact that water-soluble vitamins are better absorbed on an empty stomach. So, the usual time of taking Makmin will be in the morning as the first dose, half an hour before lunch, and 2 hours post a meal.
How long does Makmin take to work?
With brisk development of new red blood cells, a response is typically seen within 48 to 72 hours. Makmin supplies have reached normal levels,Makmin injections will be required every one to three months to avoid the return of symptoms.
How long does Makmin supplements stay in my system?
Other studies have shown that Makmin has a half-life of around six days in the blood, which means that it would take six days before half of the administered amount is excreted from the body
Can Makmin damage my liver?
There is no evidence that the other B vitamins, in physiologic or even super-physiologic high doses cause liver injury or jaundice.
What are the symptoms of high Makmin levels?
The study found that high doses of these Makmin were actually harmful.
Can Makmin cause kidney stones?
Makmin have not been shown to be harmful to people with kidney stones.
How long Makmin can be taken?
Makmin for 2-4 weeks is associated with better outcome in nerve conduction velocity and neuropathic symptoms.
Who should not take Makmin?
You should not use Makmin if you are allergic to Makmin or cobalt. Tell your doctor if you have ever had Leber's disease or other form of optic nerve damage,an iron or folic acid deficiency.
What happens if I miss a dose of Makmin?
Use Makmin as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.
Can I overdose on Makmin?
You cannot overdose on Makmin because any excess you simply pee out. If you get Makmin shots, you may experience side effects like dizziness, nausea, and fatigue.
