Malation

Malation Uses, Dosage, Side Effects, Food Interaction and all others data.

Malation is a parasympathomimetic organophosphate compound that is used as an insecticide for the treatment of head lice. Malation is an irreversible cholinesterase inhibitor and has low human toxicity.

Malation is an organophosphate insecticide commonly used to control mosquitos and other flying insects. Pharmaceutically, malathion is used to eliminate head lice. The principal toxicological effect of malathion is cholinesterase inhibition, due primarily to malaoxon and to phosphorus thionate impurities.

Trade Name Malation
Availability Prescription only
Generic Malathion
Malathion Other Names Carbophos, Karbofos, Malathion, Maldison, Mercaptothion
Related Drugs ivermectin topical, sodium chloride topical, permethrin topical, Elimite, acetic acid topical, Natroba
Type
Formula C10H19O6PS2
Weight Average: 330.358
Monoisotopic: 330.036066232
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country Lithuania
Last Updated: September 19, 2023 at 7:00 am
Malation
Malation

Uses

Malation is a parasympathomimetic organophosphate used to treat head lice.

For patients infected with Pediculus humanus capitis (head lice and their ova) of the scalp hair.

Malation is also used to associated treatment for these conditions: Head Lice Infestation

How Malation works

Malation is a nonsystemic, wide-spectrum organophosphate insecticide. It inhibits acetylcholinesterase activity of most eukaryotes. Malation is toxic to aquatic organisms, but has a relatively low toxicity for birds and mammals. The major metabolites of malathion are mono- and di-carboxylic acid derivatives, and malaoxon is a minor metabolite. However, it is malaoxon that is the strongest cholinesterase inhibitor. Cholinesterases catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. Because of its essential function, chemicals that interfere with the action of cholinesterase are potent neurotoxins, causing muscle spasms and ultimately death.

Toxicity

Malation is slightly toxic via the oral route, with reported oral LD50 values of 1000 mg/kg to greater than 10,000 mg/kg in the rat. It is also slightly toxic via the dermal route, with reported dermal LD50 values of greater than 4000 mg/kg in rats. Moderate poisoning can result in chest tightness, difficulty breathing, bradycardia, tachycardia, tremor/ataxia, blurred vision, and confusion. Severe, life-threatening signs include coma, seizures, respiratory arrest, and paralysis. Malation may also be irritating to the skin and eyes.

Food Interaction

No interactions found.

Elimination Route

Malation in an acetone vehicle has been reported to be absorbed through normal human skin only to the extent of 8% of the applied dose. Absorption may be increased when malathion is applied to damaged skin. Malation is rapidly and effectively absorbed by practically all routes including the gastrointestinal tract, skin, mucous membranes, and lungs. However, it is readily excreted in the urine, and does not accumulate in organs or tissues.

Half Life

8-24 hours

Innovators Monograph

You find simplified version here Malation

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000012
http://classyfire.wishartlab.com/tax_nodes/C0003909
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http://classyfire.wishartlab.com/tax_nodes/C0001238
http://classyfire.wishartlab.com/tax_nodes/C0003260
http://classyfire.wishartlab.com/tax_nodes/C0001438
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6651
http://www.genome.jp/dbget-bin/www_bget?cpd:C07497
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http://www.hmdb.ca/metabolites/HMDB0014910
http://www.genome.jp/dbget-bin/www_bget?drug:D00534
http://www.genome.jp/dbget-bin/www_bget?cpd:C07497
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4004
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505287
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https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6606
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http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000895
http://www.pharmgkb.org/drug/PA164748092
http://www.rxlist.com/cgi/generic3/ovide.htm
https://www.drugs.com/cdi/malathion.html
https://en.wikipedia.org/wiki/Malathion
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