Malupha
Malupha Uses, Dosage, Side Effects, Food Interaction and all others data.
Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.
Magnesium trisilicate works by increasing the pH of gastric juice via a neutralisation reaction. It also precipitates colloidal silica, which can coat gastrointestinal mucosa conferring further protection.
| Trade Name | Malupha |
| Generic | Aluminium Hydroxide and Oxide + Magnesium Trisilicate |
| Type | Suspension |
| Therapeutic Class | |
| Manufacturer | Progressive Laboratories |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Magnesium trisilicate is an antacid used for the symptomatic treatment of peptic ulcers.
For the treatment of peptic ulcers. Relieving indigestion and heartburn.
Malupha is also used to associated treatment for these conditions: Acid Reflux, Acid indigestion, Bloating, Colic, Flatulence, Gastric Ulcer, Heartburn, Upset stomach
How Malupha works
The gelatinous silicon dioxide, formed by the reaction of magnesium trisilicate with gastric contents is said to protect ulcerated mucosal surfaces and favor healing.
Toxicity
Adequate doses of magnesium trisilicate may cause diarrhea due to the action of soluble magnesium salts in the enteric tract. Approx 5% of the magnesium is absorbed.
Volume of Distribution
The hydrated silicon dioxide formed in the stomach and passes into the intestinal track.
Elimination Route
The hydrated silicon dioxide formed in the stomach and passes into the intestinal track where, silica can be partly absorbed.
Half Life
16-20 hours
Clearance
Maximum magnesium clearance is directly proportional to creatinine clearance.
Elimination Route
Excreted in the urine.
Innovators Monograph
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