Manidipino

Manidipino Uses, Dosage, Side Effects, Food Interaction and all others data.

Manidipino (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.

Manidipino produces vasodilation resulting in lower blood pressure .

Trade Name Manidipino
Generic Manidipine
Manidipine Other Names Manidipine, Manidipino
Type
Formula C35H38N4O6
Weight Average: 610.711
Monoisotopic: 610.27913496
Protein binding

Manidipine is 99% bound to human plasma proteins .

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Manidipino
Manidipino

Uses

Manidipino is a dihydropyridine calcium channel blocker used to treat hypertension.

For the treatment of hypertension.

Manidipino is also used to associated treatment for these conditions: Mild to Moderate Hypertension

How Manidipino works

Contraction of vascular smooth muscle is stimulated by Gq coupled receptors which produce calcium release from the sarcoplasmic reticulum. This is followed by opening of voltage dependent calcium channels and an influx of calcium into the cell ultimately producing contraction. Manidipino binds to and dissociates slowly from L- and T-type voltage dependent calcium channels on smooth muscle cells, blocking the entrance of extracellular calcium into the cell and preventing this contraction . This produces vasodilation which decreases blood pressure. Manidipino produces renal vasodilation and an increase in natriuresis. This likely contributes to the antihypertensive effect by reducing blood volume. Manidipino is selective for the vasculature and does not produce significant effects on the heart or central nervous system at clinically relevant dosages.

Toxicity

The most common adverse events reported in clinical trials were ankle oedema (6%), headache (3.8%), palpitation (2.7%), flushing (2.2%), dizziness (1.6%), rash (0.5%) and fatigue (0.5%) .

Elimination Route

The median Tmax is 1.5 h . Administration with food produces an 1.3-1.6-fold increase in Cmax but no change in Tmax. Manidipino does not accumulate significantly with multiple doses.

Half Life

The half life of elimination has been observed to be dose dependent . Doses of 5, 10, and 20 mg produced half lives of 3.94, 5.02, and 7.95 h respectively.

Elimination Route

Manidipino is eliminated through extensive metabolism. 63% is eliminated in the feces and 31% in the urine as metabolites .

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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