Manil
Manil Uses, Dosage, Side Effects, Food Interaction and all others data.
Manil is a musculotropic antispasmodic agent used to relieve cramps or spasms of the stomach and intestine (gut). It is particularly useful in treating Irritable Bowel Syndrome (IBS) and similar conditions. It works by relaxing the muscles and helping to restore the normal movement of the gut.
| Trade Name | Manil |
| Generic | Mebeverine |
| Mebeverine Other Names | Mebeverina, Mebeverine, Mebeverinum |
| Weight | 135mg |
| Type | Tablet |
| Formula | C25H35NO5 |
| Weight | Average: 429.557 Monoisotopic: 429.251523231 |
| Groups | Approved, Investigational |
| Therapeutic Class | Anticholinergics |
| Manufacturer | Gaco Pharmaceuticals Ltd |
| Available Country | Bangladesh |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the symptomatic treatment of Irritable Bowel Syndrome (IBS) and other conditions include:
- Chronic irritable colon
- Spastic constipation
- Mucous colitis
- Colicky abdominal pain
- Persistent non-specific diarrhea
Manil is also used to associated treatment for these conditions: Abdominal Pain, Abdominal Spasms, Abnormal Bowel Movement Such as Constipation, Diarrhea, Abdominal Pain, Irritable Bowel Syndrome (IBS), Bowel discomfort
Dosage
Manil dosage
135 mg tid, may reduce gradually after several wk when the desired effect has been obtained; 100 mg tid has also been used. As modified-release cap: 200 mg bid.
Manil is most effective when taken 20 minutes before meals. After several weeks when the desired effect has been obtained, the dosage may be gradually reduced.
Missed dose: If a dose of this medicine is missed, that should be taken as soon as possible. However, if it is almost time for the next dose, then skip the missed dose and the regular dosing schedule should be maintained. Dose should not be doubled at the same time to compensate the missed dose.
Side Effects
Generally Manil is well tolerated. However, few side-effects like skin rash, urticaria and angioedema may appear.
Precaution
Caution should be exercised in porphyria or allergic reaction to this or any other medicine of this group.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
No teratogenicity has been shown in animal experiments. However, the usual precautions concerning the administration of any drug during pregnancy should be exercised. Manil does not excrete in the breast milk after administering the therapeutic dose.
Special Warning
Use in children: Manil is not recommended in children under 10 years.
Acute Overdose
Symptoms: CNS excitability
Management: Symptomatic and supportive treatment. Gastric lavage may be considered in case of multiple intoxication or if discovered w/in approx 1 hr.
Storage Condition
Store below 30° C.
Innovators Monograph
You find simplified version here Manil
Manil contains Mebeverine see full prescribing information from innovator Manil Monograph, Manil MSDS, Manil FDA label
FAQ
What is Manil used for?
Manil helps with muscle spasms. It can be used to ease painful stomach cramps if you have irritable bowel syndrome (IBS) or other conditions.
How safe is Manil?
Manil is generally safe and you're unlikely to have side effects. Some people may get an itchy rash (hives).
How does Manil work?
Manil works by relaxing the muscles in your intestine. This relieves the cramps and pain that can be caused by IBS or other conditions.
What are the common side effects of Manil?
The common side effects of Manil are:
- Nausea.
- Vomiting.
- Rash.
- Headache.
- Heartburn.
- Indigestion.
- Constipation.
- Dizziness.
Is Manil safe during pregnancy?
Manil are not recommended during pregnancy.
Is Manil safe during breastfeeding?
It is usually safe to breastfeed while taking Manil. Some of the medicine may pass into your breast milk. However, this is in small amounts and unlikely to harm your baby.
Can I drink alcohol with Manil?
Yes, you can drink alcohol with Manil.
When should be best taken of Manil?
It's best to take your Manil 20 minutes before a meal.
How often can I take Manil?
The recommended dose is one tablet three times a day. Do not take more than three tablets per day.
Can I Manil take on an empty stomach?
Manil should take on an empty stomach. If you take it twice a day, take it before breakfast and dinner. If you take it 3 times a day, take it before breakfast, lunch and dinner.
How long does Manil take to work?
Manil starts to work after 1 hour. You should feel better 1 to 3 hours after taking it.
What is the half life of Manil?
The steady state elimination half-life of DMAC is 2.45 h.
Does Manil raise blood pressure?
Manil also significantly reduced heart rate and arterial blood pressure.
Can I take Manil for a long time?
You will usually only take Manil if you are having a flare-up of your IBS symptoms.
Who should not take Manil?
The recommended dose is one tablet three times a day. Do not take more than three tablets per day. The number of tablets you take may be lowered if your symptoms improve. Children and adolescents: Manil is not recommended for use in children and adolescents below 18 years of age.
What happen If I missed Manil?
If you miss a dose of Manil, skip the missed dose and take the next one as usual. Do not take a double dose to make up for a missed dose. If you forget doses often, it may help to set an alarm to remind you.
What happens if I take too much Manil?
If you take too much Manil by accident, it is unlikely to harm you. Speak to a pharmacist or doctor if you're worried.
Can I just stop taking Manil?
You can stop taking Manil when you feel better. This may take up to 2 weeks. If you do not get better within 2 weeks of taking Manil, or get worse at any time, talk to a doctor.
Does Manil raise blood pressure?
Manil also significantly reduced heart rate and arterial blood pressure.
Does Manil cause tachycardia?
Transient bradycardia followed by tachycardia.
